INT34440

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Context Info
Confidence 0.59
First Reported 1983
Last Reported 1999
Negated 2
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 0
Pain Relevance 5.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
plasma 6
brainstem 2
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 99.98 Very High Very High Very High
dexamethasone 8 99.80 Very High Very High Very High
Enkephalin 20 99.72 Very High Very High Very High
medulla 4 99.48 Very High Very High Very High
fluoxetine 6 99.34 Very High Very High Very High
Hippocampus 2 99.24 Very High Very High Very High
narcan 12 99.20 Very High Very High Very High
antagonist 3 99.00 Very High Very High Very High
Potency 3 99.00 Very High Very High Very High
opiate 11 97.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DMI pretreatment blocked the increase in hippocampal TRH, but not in brainstem TRH.
Negative_regulation (blocked) of Positive_regulation (increase) of TRH in brainstem associated with medulla
1) Confidence 0.59 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 3928818 Disease Relevance 0 Pain Relevance 0.45
FX pretreatment was ineffective in blocking any increases in TRH content.
Negative_regulation (blocking) of Positive_regulation (increases) of TRH associated with fluoxetine
2) Confidence 0.43 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 3928818 Disease Relevance 0 Pain Relevance 0.45
Both opiates (morphine, 10(-6) M; leucine enkephalin, 10(-6) M) did not modify the spontaneous release of TRH, but significantly decreased the depolarization-induced TRH release.
Neg (not) Negative_regulation (decreased) of Positive_regulation (depolarization-induced) of TRH associated with enkephalin, opiate and morphine
3) Confidence 0.43 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6412152 Disease Relevance 0 Pain Relevance 0.85
Perfusion with 10(-6)M morphine blocked the cold-induced TRH peak occurring about 40 min after the transfer of rats from 24 degrees C to 4 degrees C.
Negative_regulation (blocked) of Positive_regulation (cold-induced) of TRH associated with morphine
4) Confidence 0.43 Published 1986 Journal Life Sci. Section Abstract Doc Link 3079851 Disease Relevance 0 Pain Relevance 0.59
Perfusion with 10(-6)M morphine blocked the cold-induced TRH peak occurring about 40 min after the transfer of rats from 24 degrees C to 4 degrees C.
Negative_regulation (blocked) of Positive_regulation (occurring) of TRH associated with morphine
5) Confidence 0.43 Published 1986 Journal Life Sci. Section Abstract Doc Link 3079851 Disease Relevance 0 Pain Relevance 0.60
The calmodulin antagonists trifluoperazine and triflupromazine (50 mumol/l) inhibited veratridine-stimulated TRH release.
Negative_regulation (inhibited) of Positive_regulation (veratridine-stimulated) of TRH associated with antagonist
6) Confidence 0.43 Published 1987 Journal J. Endocrinol. Section Abstract Doc Link 3125299 Disease Relevance 0 Pain Relevance 0.19
TRH and TSH responses to cold were inhibited after L-EK administration.
Negative_regulation (inhibited) of Positive_regulation (responses) of TRH associated with enkephalin
7) Confidence 0.42 Published 1983 Journal Life Sci. Section Abstract Doc Link 6401835 Disease Relevance 0 Pain Relevance 0.59
Basal thyrotropin (TSH) levels in plasma and the TSH response to thyrotropin-releasing hormone (TRH) were inhibited after Leucine-enkephalin (L-EK) administration iv in rats.
Negative_regulation (inhibited) of Positive_regulation (response) of thyrotropin-releasing hormone in plasma associated with enkephalin
8) Confidence 0.42 Published 1983 Journal Life Sci. Section Abstract Doc Link 6401835 Disease Relevance 0 Pain Relevance 0.56
Basal thyrotropin (TSH) levels in plasma and the TSH response to thyrotropin-releasing hormone (TRH) were inhibited after Leucine-enkephalin (L-EK) administration iv in rats.
Negative_regulation (inhibited) of Positive_regulation (response) of TRH in plasma associated with enkephalin
9) Confidence 0.42 Published 1983 Journal Life Sci. Section Abstract Doc Link 6401835 Disease Relevance 0 Pain Relevance 0.56
TRH stimulation of IP3 formation was inhibited by high GDP concentrations.
Negative_regulation (inhibited) of Positive_regulation (stimulation) of TRH
10) Confidence 0.40 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 3036863 Disease Relevance 0 Pain Relevance 0.05
However, the PRL increase after TRH was not suppressed by pretreatment with BRC. 3) Naloxone had no significant effect on PRL response to MCP and TRH, since the plasma PRL levels rose significantly after the injection of MCP and TRH in the naloxone-treated group.
Neg (not) Negative_regulation (suppressed) of Positive_regulation (increase) of TRH in plasma associated with narcan
11) Confidence 0.13 Published 1987 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 3112295 Disease Relevance 0 Pain Relevance 0.20
On day 3, dexamethasone caused a reduced response of Prl to TRH.
Negative_regulation (reduced) of Positive_regulation (response) of TRH associated with dexamethasone
12) Confidence 0.06 Published 1999 Journal Horm. Res. Section Abstract Doc Link 10352398 Disease Relevance 0 Pain Relevance 0.62

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