INT34441

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Context Info
Confidence 0.42
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.76
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Pck1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 24 100.00 Very High Very High Very High
tolerance 8 99.62 Very High Very High Very High
Antinociceptive 8 99.42 Very High Very High Very High
Buprenorphine 8 98.24 Very High Very High Very High
Opioid 13 97.28 Very High Very High Very High
Analgesic 8 96.72 Very High Very High Very High
antagonist 9 95.16 Very High Very High Very High
mu opioid receptor 9 94.96 High High
Potency 3 90.56 High High
Spinal cord 2 83.56 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 9 97.12 Very High Very High Very High
Vibrio Infection 3 92.80 High High
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Stroke 1 5.00 Very Low Very Low Very Low
Pruritus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of buprenorphine to rats produced a long-lasting (>24 h) decrease in mu and kappa2 receptor binding and attenuated mu-stimulated [(35)S]-GTP-gamma-S binding.
Negative_regulation (attenuated) of GTP Binding (binding) of associated with buprenorphine
1) Confidence 0.42 Published 1999 Journal Synapse Section Abstract Doc Link 10502307 Disease Relevance 0 Pain Relevance 1.15
On the other hand, the PTX-sensitive subunits, G alpha i2 and G alpha o, as well as agonist-stimulated [35S]GTP gamma S binding were still reduced.
Negative_regulation (reduced) of GTP Binding (binding) of associated with agonist
2) Confidence 0.42 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18384820 Disease Relevance 0.14 Pain Relevance 1.06
Seven days of chronic sufentanil treatment developed antinociceptive tolerance associated with a reduction in mu-agonist-induced [35S]GTP gamma S binding, mu-agonist-induced adenylyl cyclase inhibition, and co-precipitation of G alpha o, G alpha i2 G alpha z and G alpha q11 subunits with mu-opioid receptors.
Negative_regulation (reduction) of GTP Binding (binding) of associated with mu opioid receptor, agonist, tolerance and antinociceptive
3) Confidence 0.41 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18384820 Disease Relevance 0.17 Pain Relevance 1.07
Maximally effective concentrations of GTP gamma S, Gpp(NH)p, GTP, and GDP decreased specific [3H]Me-TRH binding by 80%.
Negative_regulation (decreased) of GTP Binding (binding) of
4) Confidence 0.12 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 3036863 Disease Relevance 0.16 Pain Relevance 0.29
In all cases, the unlabeled (‘cold’) form of the nucleoside triphosphate was a competitive inhibitor of the binding of the radioactive form but GTP did not compete for 32P ATP binding and ATP did not compete for 32P GTP binding.
Negative_regulation (inhibitor) of GTP Binding (binding) of
5) Confidence 0.10 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0
Peptide i3.1 also inhibited DAMGO-stimulated [35S]guanosine-5'-O-(3-thio)triphosphate ([35S]GTP-gammaS) binding in the same membranes.
Negative_regulation (inhibited) of GTP-gammaS Binding (binding) of
6) Confidence 0.02 Published 1997 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9434132 Disease Relevance 0.29 Pain Relevance 0.24

General Comments

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