INT344416

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.31
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Siglec5)
Anatomy Link Frequency
smooth muscle 1
lung 1
bronchus 1
Siglec5 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 48 89.60 High High
chemokine 30 79.24 Quite High
cytokine 84 78.64 Quite High
Inflammation 114 69.12 Quite High
anesthesia 12 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 54 89.60 High High
Airway Remodeling 156 88.72 High High
INFLAMMATION 120 69.12 Quite High
Asthma 84 57.80 Quite High
Occupational Lung Diseases 6 45.00 Quite Low
Rhinitis 72 27.12 Quite Low
Apoptosis 24 5.00 Very Low Very Low Very Low
Hypereosinophilic Syndrome 6 5.00 Very Low Very Low Very Low
Hypertrophy 6 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we examined whether removal of the Siglec-F receptor in Siglec-F deficient mice influenced levels of Siglec-F ligand expression.
Spec (whether) Negative_regulation (removal) of Siglec-F receptor
1) Confidence 0.55 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.50 Pain Relevance 0.06
In this study we examined whether removal of the Siglec-F receptor in Siglec-F deficient mice influenced levels of Siglec-F ligand expression.
Spec (whether) Negative_regulation (removal) of Siglec-F
2) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.50 Pain Relevance 0.06
Siglec-F deficient mice challenged with OVA had a significant increase in the percentage of PAS+ mucus cells compared to OVA challenged WT mice (42.7 ± 3.5 vs 21.8 ± 3.0% PAS+ cells/bronchus)(Siglec-F deficient OVA vs WT OVA)(p < 0.0001)(Figure 2A-2E).


Negative_regulation (deficient) of Siglec-F in bronchus
3) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.17 Pain Relevance 0.09
Chronic OVA challenged Siglec-F deficient mice have increased numbers of peribronchial TGF-?
Negative_regulation (deficient) of Siglec-F
4) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.14 Pain Relevance 0.07
Chronic OVA challenged Siglec-F deficient mice have increased smooth muscle thickness
Negative_regulation (deficient) of Siglec-F in smooth muscle
5) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.03
Levels of lung IL-5 (Figure 5A) and IL-13 (Figure 5B) were similar in OVA challenged Siglec-F deficient and OVA challenged WT mice.
Negative_regulation (deficient) of Siglec-F in lung
6) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.08

General Comments

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