INT344420

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.40 Pain Relevance 0.05

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s) endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)

Anatomy Link Frequency eosinophils 1 Ltc4s (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 14 99.72 Inflammation 19 5.00 fibrosis 8 5.00 chemokine 5 5.00 anesthesia 2 5.00 ketamine 1 5.00 Inflammatory response 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Airway Remodeling 26 87.12 Asthma 14 74.96 Hypertrophy 1 71.36 Fibrosis 9 23.36 INFLAMMATION 20 5.00 Rhinitis 12 5.00 Apoptosis 4 5.00 Occupational Lung Diseases 1 5.00 Hypereosinophilic Syndrome 1 5.00 Peripheral Arterial Disease 1 5.00

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Protein

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One possible explanation is that the increased numbers of eosinophils in the airway in Siglec-F deficient mice express increased levels of mediators that can influence mucus secretion including granule mediators (ECP, MBP)[29,30], lipid mediators (LTC4)[31], cytokines (IL-13)[31], or other at present unknown mediators.

Localization (secretion) of LTC4 in eosinophils associated with cytokine

1) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.40 Pain Relevance 0.05

General Comments

This test has worked.