INT344421

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Context Info
Confidence 0.66
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.31
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Siglec5)
Anatomy Link Frequency
lung 2
blood 1
smooth muscle 1
epithelium 1
extracellular matrix 1
Siglec5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 152 96.28 Very High Very High Very High
fibrosis 64 95.86 Very High Very High Very High
cytokine 112 76.44 Quite High
chemokine 40 73.92 Quite High
anesthesia 16 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 160 96.28 Very High Very High Very High
Fibrosis 72 95.86 Very High Very High Very High
Airway Remodeling 208 95.38 Very High Very High Very High
Asthma 112 62.16 Quite High
Rhinitis 96 50.56 Quite High
Occupational Lung Diseases 8 49.36 Quite Low
Apoptosis 32 5.00 Very Low Very Low Very Low
Hypereosinophilic Syndrome 8 5.00 Very Low Very Low Very Low
Hypertrophy 8 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(p = ns) did not induce significant Siglec-F ligand expression by airway epithelium (p = ns) but induced a slight but statistically significant increase in Siglec-F ligand expressing peribronchial cells (p < 0.01) (Fig. 7E-F).
Positive_regulation (increase) of Siglec-F in epithelium
1) Confidence 0.66 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.03
We have previously demonstrated that levels of Siglec-F are upregulated on blood eosinophils following OVA challenge [5].
Positive_regulation (upregulated) of Siglec-F in blood
2) Confidence 0.66 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.51 Pain Relevance 0.03
Levels of lung eotaxin-1 (p < 0.04)(Figure 5C), and RANTES (p < 0.02)(Figure 5D) were increased in Siglec-F deficient compared to WT mice challenged with OVA.


Positive_regulation (increased) of Siglec-F in lung
3) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.07
induced a significant BAL neutrophil response in both WT (p = 0.03)(Figure 7I) and Siglec-F deficient mice (p = 0.03)(Figure 7I).
Positive_regulation (induced) of Siglec-F in neutrophil
4) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.04
In this study we have utilized Siglec-F deficient mice to demonstrate an important role for Siglec-F in modulating levels of airway remodeling (peribronchial fibrosis, thickness of the smooth muscle layer), mucus expression, deposition of extracellular matrix proteins such as fibronectin, as well as an important role for Siglec-F in regulating levels of chronic allergen induced peribronchial Siglec-F ligands.
Positive_regulation (induced) of Siglec-F in extracellular matrix associated with fibrosis and airway remodeling
5) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.29 Pain Relevance 0.08
Chronic OVA challenged Siglec-F deficient mice express increased levels of peribronchial Siglec-F ligands
Positive_regulation (increased) of Siglec-F
6) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.07
This increase in level of peribronchial Siglec-F ligands in Siglec-F deficient mice is most likely accounted for by the increased numbers of inflammatory cells expressing Siglec-F ligands (i.e. eosinophils, macrophages) recruited to the airway following OVA challenge, though we cannot rule out a contribution from upregulation of Siglec-F ligand expression by inflammatory cells recruited to the lung.
Positive_regulation (increase) of Siglec-F in lung associated with inflammation
7) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.51 Pain Relevance 0.09
Siglec-F deficient mice challenged chronically with OVA had a modest (approximately 20%), but statistically significant, increase in the thickness of the peribronchial smooth muscle layer (6.3 ± 0.2 vs 5.3 ± 0.2 µm)(p < 0.003) (Siglec-F deficient mice OVA vs WT OVA)(Figure 8A) compared to OVA challenged WT mice.


Positive_regulation (increase) of Siglec-F in smooth muscle
8) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0

General Comments

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