INT344428

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.46
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cell adhesion (Siglec5)
cytoplasm (Il13)
Anatomy Link Frequency
epithelium 4
Il13 (Mus musculus)
Siglec5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 42 95.84 Very High Very High Very High
fibrosis 24 77.96 Quite High
Inflammation 57 64.00 Quite High
chemokine 15 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 27 77.96 Quite High
Asthma 42 77.84 Quite High
Rhinitis 36 65.60 Quite High
INFLAMMATION 60 64.00 Quite High
Airway Remodeling 78 38.92 Quite Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 3 5.00 Very Low Very Low Very Low
Hypereosinophilic Syndrome 3 5.00 Very Low Very Low Very Low
Hypertrophy 3 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Siglec-F deficient mice, similar results were observed with both IL-4 and IL-13 inducing increased Siglec-F ligand expression to a similar degree in both peribronchial cells (Figure 7E) and airway epithelium (Figure 7F), while TNF?
IL-13 Positive_regulation (inducing) of Gene_expression (expression) of Siglec-F in epithelium
1) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.04
Although both IL-4 and IL-13 induced strong upregulation of Siglec-F ligand expression by airway epithelium in both WT and Siglec-F deficient mice (Figure 7F), levels of Siglec-F ligands in airway epithelium were slightly lower in Siglec-F deficient vs WT mice induced by IL-13 (p = 0.02) but not IL-4 (p = 0.10) (Figure 7F).
IL-13 Positive_regulation (upregulation) of Gene_expression (expression) of Siglec-F in epithelium
2) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.05
WT and Siglec-F deficient mice challenged intranasally with IL-4 or IL-13 had significantly increased levels of airway epithelial Siglec-F ligand expression, whereas this was not observed in WT or Siglec-F deficient mice challenged with TNF-?.
IL-13 Positive_regulation (increased) of Gene_expression (expression) of Siglec-F
3) Confidence 0.27 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2988013 Disease Relevance 0.46 Pain Relevance 0.13

General Comments

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