INT34444

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 1987
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.18
Pain Relevance 4.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ptprg) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Oprl1 (Rattus norvegicus)
Ptprg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 32 100.00 Very High Very High Very High
opioid receptor 30 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
agonist 22 99.64 Very High Very High Very High
Opioid 16 99.44 Very High Very High Very High
mu opioid receptor 8 99.00 Very High Very High Very High
narcan 6 98.24 Very High Very High Very High
Analgesic 4 93.48 High High
Immobilon 2 90.08 High High
Endogenous opioid 2 86.72 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 98.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to its lack of effect on TRH receptor binding, 3-h pertussis toxin treatment decreased agonist affinity of the mu-opiate receptor and abolished the ability of GTP gamma S to shift the affinity of the mu-opiate receptor for its agonist.
mu-opiate receptor Binding (affinity) of GTP gamma S associated with bordatella infection, agonist and opiate
1) Confidence 0.03 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 3036863 Disease Relevance 0.18 Pain Relevance 0.37
Unlike OFQ II(1-17), high concentrations of its C-terminal extension, OFQ II(1-28), stimulated [35S]-GTPgammaS binding in a mu (mu) opioid receptor-like distribution and the effect was blocked by naloxone.
opioid receptor-like Binding (binding) of GTPgammaS associated with narcan and opioid receptor
2) Confidence 0.01 Published 2003 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12842269 Disease Relevance 0 Pain Relevance 0.70
Taken together, these findings support the view that (1) OFQ is the only ppOFQ peptide that binds to and activates the ORL1 receptor and (2) OFQ II(1-28) does not bind or stimulate [35S]-GTPgammaS binding in cells expressing the mu opioid receptor.
ORL1 receptor Binding (binding) of GTPgammaS associated with mu opioid receptor
3) Confidence 0.01 Published 2003 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12842269 Disease Relevance 0 Pain Relevance 0.58
The affinity and functional profile of opioids possessing activity at the nociceptin receptor was determined using [3H]nociceptin and nociceptin-stimulated [35S]GTPgammaS binding.
nociceptin receptor Binding (binding) of GTPgammaS associated with orphanin and opioid
4) Confidence 0.00 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10688973 Disease Relevance 0 Pain Relevance 1.33
Lofentanil exhibited full agonism for enhancement of [35S]GTPgammaS binding to human recombinant ORL1 receptors (EC(50) 50 nM).
ORL1 Binding (binding) of GTPgammaS
5) Confidence 0.00 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10688973 Disease Relevance 0 Pain Relevance 1.59

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox