INT34460

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 1987
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.95
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MBTPS1) Golgi apparatus (MBTPS1) endoplasmic reticulum (MBTPS1)
lipid metabolic process (MBTPS1)
Anatomy Link Frequency
pore 1
kidney 1
MBTPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
local anesthetic 4 100.00 Very High Very High Very High
sodium channel 3 98.58 Very High Very High Very High
substance P 2 89.16 High High
bradykinin 2 88.16 High High
potassium channel 1 85.12 High High
Analgesic 5 79.08 Quite High
tetrodotoxin 3 73.76 Quite High
metalloproteinase 1 72.44 Quite High
Neuropeptide 1 64.12 Quite High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 2 92.56 High High
Disease 48 88.80 High High
Toxicity 29 88.00 High High
Natriuresis 1 87.28 High High
Nociception 1 83.20 Quite High
Hypertension 1 78.28 Quite High
Adhesions 10 60.44 Quite High
Pancreatic Cancer 6 29.36 Quite Low
Cancer 8 28.16 Quite Low
Immune System Diseases 4 27.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.
endopeptidase Binding (complexed) of
1) Confidence 0.24 Published 2000 Journal J. Mol. Biol. Section Title Doc Link 10669592 Disease Relevance 0.25 Pain Relevance 0.29
Our study indicated that neurotensin(1-10) formation by porcine endopeptidase 3.4.24.16 could be potently blocked with the selective endopeptidase 3.4.24.16 dipeptide inhibitor Pro-Ile without interfering with neurotensin(1-8) formation.
endopeptidase Binding (formation) of
2) Confidence 0.15 Published 1996 Journal Brain Res. Section Abstract Doc Link 8869556 Disease Relevance 0 Pain Relevance 0.17
Protein functional groups statistically enriched with proteins with domain altering SNPs include calcium ion binding, adenyl ribonucleotide binding, protein kinase activity, endopeptidase activity, serine-type peptidase activity, DNA binding, and GTPase binding proteins.


endopeptidase Binding (binding) of
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944825 Disease Relevance 0.24 Pain Relevance 0
Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding.
site 1 toxin Binding (binding) of in pore associated with sodium channel and local anesthetic
4) Confidence 0.08 Published 2006 Journal J Mol Model Section Title Doc Link 16508760 Disease Relevance 0 Pain Relevance 0.59
Protein functional groups statistically enriched with proteins with domain altering SNPs include calcium ion binding, adenyl ribonucleotide binding, protein kinase activity, endopeptidase activity, serine-type peptidase activity, DNA binding, and GTPase binding proteins.


endopeptidase Binding (binding) of
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944825 Disease Relevance 0.24 Pain Relevance 0
Based on the model prediction and field measurements, the OCRR site was generally associated with low pyrethroid TU relative to the other sites.
OCRR site Binding (associated) of
6) Confidence 0.05 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016336 Disease Relevance 0.22 Pain Relevance 0
Various angiotensins, bradykinins, and related peptides were examined for their inhibitory activity against several enkephalin-degrading enzymes, including an aminopeptidase and a dipeptidyl aminopeptidase, purified from a membrane-bound fraction of monkey brain, and an endopeptidase, purified from the rabbit kidney membrane fraction.
endopeptidase Spec (examined) Binding (activity) of in kidney associated with enkephalin
7) Confidence 0.03 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3037031 Disease Relevance 0 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox