INT34465

Context Info Confidence 0.45 First Reported 1984 Last Reported 2010 Negated 5 Speculated 8 Reported most in Abstract Documents 34 Total Number 42 Disease Relevance 7.14 Pain Relevance 34.29

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency brain 3 plasma 2 spinal cord 1 NG108-15 1 striatum 1 Oprd1 (Mus musculus)

Pain Link Frequency Relevance Heat opioid receptor 253 100.00 agonist 133 100.00 Pain 93 100.00 Enkephalin 61 100.00 Opioid 51 100.00 Analgesic 43 100.00 antagonist 34 100.00 Dopamine 30 100.00 Spinal cord 28 100.00 Delta opioid receptors 22 100.00

Disease Link Frequency Relevance Heat Attention Deficit Hyperactivity Disorder 63 99.60 Stress 11 99.36 Targeted Disruption 48 99.08 Inflammatory Pain 13 98.88 Tics 3 98.86 Nociception 11 98.52 Pain 96 98.08 Appetite Loss 2 95.52 Ocular Toxicity (including Many Sub-types) 4 94.36 Drug Dependence 11 91.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects of selective opioid delta-receptor antagonists on stress-induced antinociception and plasma corticosterone levels in mice.

Regulation (effects) of opioid delta-receptor in plasma associated with stress, antinociception, antagonist, narcan and opioid

1) Confidence 0.45 Published 1985 Journal Neuropeptides Section Title Doc Link 3839053 Disease Relevance 0.10 Pain Relevance 0.67

These data suggest that altered DOR mRNA levels are not one of the adaptive changes that occur with delta opioid ([D-Ala2]deltorphin II) tolerance.

Regulation (altered) of DOR mRNA associated with tolerance, opioid receptor and opioid

2) Confidence 0.45 Published 1994 Journal J. Neurosci. Res. Section Abstract Doc Link 7897702 Disease Relevance 0 Pain Relevance 0.52

Finally, beyond addiction, the role of the Oprm1 and Oprd1 genes in impulsivity has implications for understanding and treating attention deficit hyperactivity disorder, eating disorders, gambling and other disorders of impulse control.

Regulation (role) of Oprd1 associated with appetite loss, addiction and attention deficit hyperactivity disorder

3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 0.93 Pain Relevance 0.23

However, despite the functional increase in DOR sensitivity, the DOR mRNA levels in selected brain areas and spinal cord of naltrexone-treated and control mice did not differ.

Neg (not) Regulation (differ) of DOR mRNA in brain associated with opioid receptor and spinal cord

4) Confidence 0.45 Published 1995 Journal Brain Res. Section Abstract Doc Link 8590066 Disease Relevance 0 Pain Relevance 0.92

Effects of highly selective delta-opioid receptor antagonists on the morphine-induced place preference in ddY and mu 1-opioid receptor deficient CXBK mice were investigated.

Spec (investigated) Regulation (Effects) of delta-opioid receptor associated with antagonist, opioid receptor and morphine

5) Confidence 0.42 Published 1994 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7861658 Disease Relevance 0 Pain Relevance 0.78

The present study was designed to determine, with the tail-flick method, whether the stimulatory effect of delta-opioid receptor agonists on phospholipase C and inositol lipid turnover participates in the mechanisms of the delta-opioid receptor-mediated antinociception in the mouse spinal cord.

Spec (whether) Regulation (effect) of delta-opioid receptor in spinal cord associated with antinociception, agonist, tail-flick, opioid receptor and spinal cord

6) Confidence 0.41 Published 2000 Journal Neuroscience Section Abstract Doc Link 10938438 Disease Relevance 0 Pain Relevance 0.84

Differences in the effects of mu- and delta-opioid receptor antagonists upon plasma corticosterone levels in stressed mice.

Regulation (effects) of delta-opioid in plasma associated with antagonist, narcan and opioid receptor

7) Confidence 0.39 Published 1984 Journal Eur. J. Pharmacol. Section Title Doc Link 6086360 Disease Relevance 0 Pain Relevance 0.58

The effects of dopamine D1 and D2 receptor antagonists on the rewarding effects of delta 1 and delta 2 opioid receptor agonists in mice.

Regulation (effects) of delta 2 opioid receptor associated with dopamine, antagonist, agonist, enkephalin and opioid receptor

8) Confidence 0.37 Published 1996 Journal Psychopharmacology (Berl.) Section Title Doc Link 8740041 Disease Relevance 0 Pain Relevance 1.04

The effects of chronic administration and subsequent withdrawal of mu-, kappa- and delta-opioid receptor agonists on the levels of cyclic GMP in several brain regions and spinal cord of mice were determined in an attempt to further study the role of NO cascade in opioid actions.

Regulation (effects) of delta-opioid receptor in brain associated with agonist, opioid receptor, opioid, withdrawal and spinal cord

9) Confidence 0.34 Published 1997 Journal Peptides Section Abstract Doc Link 9437726 Disease Relevance 0 Pain Relevance 0.85

The reactivation effects of the delta-opioid receptor blockade and D2 dopamine receptor activation on the detention-induced memory deficit in mice were investigated, in order to study possible interactions between opioid and dopamine systems in memory retrieval.

Spec (investigated) Regulation (effects) of delta-opioid receptor associated with dopamine, dopamine receptor, opioid receptor and opioid

10) Confidence 0.32 Published 1996 Journal Behav. Brain Res. Section Abstract Doc Link 8883813 Disease Relevance 0 Pain Relevance 0.41

The present study was designed to investigate the effect of repeated administration of a selective kappa-opioid receptor agonist (1S-trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide hydrochloride ((-)U-50,488H) on the mu- and delta-opioid receptor agonist-induced antinociception and G-protein activation in mice.

Spec (investigate) Regulation (effect) of delta-opioid receptor associated with antinociception, agonist, kappa opioid receptor and opioid receptor

11) Confidence 0.29 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975677 Disease Relevance 0 Pain Relevance 0.92

These data demonstrate that DOR mRNA levels are not altered during and after chronic naltrexone treatment and therefore are not associated with opioid-induced DOR up-regulation or DOR functional supersensitivity.

Neg (not) Regulation (altered) of DOR mRNA associated with opioid receptor and opioid

12) Confidence 0.27 Published 1995 Journal Brain Res. Section Abstract Doc Link 8590066 Disease Relevance 0 Pain Relevance 0.84

Intracerebroventricular administration of a 20mer antisense or a mismatch control oligodeoxynucleotide (ODN) targeting the mRNA of the cloned delta opioid receptor (DOR-1) for 3 days did not affect baseline nociceptive thresholds or morphine analgesia compared to untreated or saline-treated mice.

Regulation (targeting) of delta opioid receptor associated with nociception, opioid receptor, intracerebroventricular, analgesia and morphine

13) Confidence 0.27 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 8866695 Disease Relevance 0.26 Pain Relevance 1.26

Intracerebroventricular administration of a 20mer antisense or a mismatch control oligodeoxynucleotide (ODN) targeting the mRNA of the cloned delta opioid receptor (DOR-1) for 3 days did not affect baseline nociceptive thresholds or morphine analgesia compared to untreated or saline-treated mice.

Regulation (targeting) of DOR-1 associated with nociception, opioid receptor, intracerebroventricular, analgesia and morphine

14) Confidence 0.27 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 8866695 Disease Relevance 0.26 Pain Relevance 1.26

Blockade of morphine supersensitivity by an antisense oligodeoxynucleotide targeting the delta opioid receptor (DOR-1).

Regulation (targeting) of delta opioid receptor associated with analgesic, opioid receptor and morphine

15) Confidence 0.27 Published 1997 Journal Life Sci. Section Title Doc Link 9048971 Disease Relevance 0.08 Pain Relevance 0.98

Blockade of morphine supersensitivity by an antisense oligodeoxynucleotide targeting the delta opioid receptor (DOR-1).

Regulation (targeting) of DOR-1 associated with analgesic, opioid receptor and morphine

16) Confidence 0.27 Published 1997 Journal Life Sci. Section Title Doc Link 9048971 Disease Relevance 0.08 Pain Relevance 0.98

[Protective effects of a delta-opioid-receptor agonist and an oxygen radical scavenger on postischemic hearts].

Regulation (effects) of delta-opioid-receptor in hearts associated with agonist and opioid

17) Confidence 0.27 Published 2004 Journal Herz Section Title Doc Link 15167961 Disease Relevance 0.09 Pain Relevance 0.41

Peripheral antinociceptive effects of mu- and delta-opioid receptor agonists in NOS2 and NOS1 knockout mice during chronic inflammatory pain.

Regulation (effects) of delta-opioid receptor associated with targeted disruption, analgesic, ipn, agonist, opioid receptor and antinociceptive

18) Confidence 0.26 Published 2009 Journal Eur. J. Pharmacol. Section Title Doc Link 19041302 Disease Relevance 1.19 Pain Relevance 1.87

The data also indicate that delta2-opioid receptors are critically involved in the expression of morphine supersensitivity.

Regulation (involved) of delta2-opioid associated with opioid receptor and morphine

19) Confidence 0.26 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9593593 Disease Relevance 0 Pain Relevance 1.13

ODN targeting a 20-nucleotide sequence of the DOR mRNA transcript was administered by intracerebroventricular (i.c.v.) injection twice daily for 3 days.

Regulation (targeting) of DOR mRNA associated with opioid receptor and intracerebroventricular

20) Confidence 0.25 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9379841 Disease Relevance 0.17 Pain Relevance 0.95

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