INT344674

Context Info Confidence 0.42 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.17 Pain Relevance 0

Bas (Mus musculus)

Pain Link Frequency Relevance Heat agonist 25 5.00 Inflammation 11 5.00 aspirin 5 5.00 Bile 5 5.00 antagonist 4 5.00 Angina 3 5.00 tolerance 3 5.00 imagery 2 5.00 cytokine 1 5.00 adenocard 1 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 300 99.16 Coronary Heart Disease 70 90.80 Atherosclerosis 56 83.04 Targeted Disruption 4 76.40 Myocardial Infarction 22 5.00 Increased Venous Pressure Under Development 20 5.00 Hypoalphalipoproteinemias 16 5.00 Metabolic Syndrome 12 5.00 Diabetes Mellitus 12 5.00 INFLAMMATION 11 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This information in the recent years led to intense interest in the development of CETP inhibitors as therapeutic agents for raising HDL.27,28 Individuals homozygous for the CETP mutation that leads to its dysfunction or deficiency, have been shown to be associated with elevations in HDL exceeding 100%, along with more than 40% decrease in the level of LDL and apo-B as compared with familial controls.

Negative_regulation (decrease) of B as associated with disorder of lipid metabolism

1) Confidence 0.42 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.17 Pain Relevance 0

General Comments

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