INT34472

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Context Info
Confidence 0.03
First Reported 1987
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) extracellular region (Penk) plasma membrane (Slc3a1)
carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
neurons 1
Penk (Rattus norvegicus)
Slc3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
Opioid receptor 1 2 100.00 Very High Very High Very High
antagonist 2 98.36 Very High Very High Very High
narcan 4 97.92 Very High Very High Very High
Central grey 6 96.84 Very High Very High Very High
Opioid 2 86.68 High High
Dynorphin 1 82.08 Quite High
MU agonist 1 75.00 Quite High
opioid receptor 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 96.84 Very High Very High Very High
Increased Venous Pressure Under Development 2 67.28 Quite High
Bordatella Infection 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas the effects of beta-endorphin, DAGO and [D-Ala2,D-Leu5]enkephalin could be reduced by the mu-preferential antagonist naloxone, the effects of ethylketocyclazocine and U-50488 were not changed.
enkephalin Regulation (effects) of D-Ala2 associated with antagonist, narcan and enkephalin
1) Confidence 0.03 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3037389 Disease Relevance 0.07 Pain Relevance 1.24
The effect of mu-type opioid receptor agonist, D-Ala2,N-MePhe4,Gly5-ol-enkephalin (DAMGO), on high-voltage-activated (HVA) Ca2+ channels in the dissociated rat periaqueductal gray (PAG) neurons was investigated by the use of nystatin-perforated patch recording mode under voltage-clamp condition.
Gly5-ol-enkephalin Regulation (effect) of D-Ala2 in neurons associated with agonist, opioid receptor 1, enkephalin and central grey
2) Confidence 0.00 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9084607 Disease Relevance 0.35 Pain Relevance 0.50

General Comments

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