INT34474

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 1.28
Pain Relevance 9.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 6
plasma 2
substantia nigra 2
brain 2
neural 2
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 262 100.00 Very High Very High Very High
GABA receptor 14 100.00 Very High Very High Very High
Ventral tegmentum 1 99.68 Very High Very High Very High
agonist 47 99.60 Very High Very High Very High
Dopamine 85 99.50 Very High Very High Very High
Morphine 13 99.34 Very High Very High Very High
Serotonin 4 99.04 Very High Very High Very High
Antinociceptive 10 98.96 Very High Very High Very High
Nicotine 38 98.92 Very High Very High Very High
Substantia nigra 1 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Congenital Anomalies 6 97.72 Very High Very High Very High
Pain 8 97.52 Very High Very High Very High
Convulsion 39 96.00 Very High Very High Very High
Stress 5 88.36 High High
Fetal Death 1 86.76 High High
Toxicity 1 83.92 Quite High
Nociception 19 79.04 Quite High
Neuropathic Pain 9 70.44 Quite High
Depression 1 62.48 Quite High
Ganglion Cysts 57 54.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in CeA neurons of HET mice, the previously characterized ethanol-induced increase of GABAA-IPSPs was abolished.
Negative_regulation (abolished) of Positive_regulation (increase) of GABAA in neurons associated with amygdala
1) Confidence 0.57 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.15 Pain Relevance 0.37
These data indicate allopregnanolone increases and DHEAS decreases responsiveness of GnRH neurons to activation of GABAA receptors by differentially modulating current flow through GABAA receptor chloride channels.
Negative_regulation (decreases) of Positive_regulation (activation) of GABAA in neurons
2) Confidence 0.55 Published 2003 Journal Endocrinology Section Abstract Doc Link 12960018 Disease Relevance 0 Pain Relevance 0.26
The data suggest that an alteration of GABA(B) receptors could contribute to the reduced efficacy of R-baclofen to suppress hippocampal epileptiform activity in weaver mice, while the suppression by adenosine remains largely unaffected.
Negative_regulation (suppress) of Positive_regulation (alteration) of GABA associated with adenocard and gaba
3) Confidence 0.40 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10670420 Disease Relevance 0 Pain Relevance 0.58
Treatment with THIP (15 mg/kg) was found to block the antinociceptive response to an inhibitor of the uptake of GABA, an inhibitor of GABA-transaminase, a direct-acting GABA receptor agonist and to a cholinesterase inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (direct-acting) of GABA associated with gaba, gaba receptor, agonist and antinociceptive
4) Confidence 0.37 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 3037414 Disease Relevance 0 Pain Relevance 0.88
Treatment with THIP (15 mg/kg) was found to block the antinociceptive response to an inhibitor of the uptake of GABA, an inhibitor of GABA-transaminase, a direct-acting GABA receptor agonist and to a cholinesterase inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (direct-acting) of GABA associated with gaba, gaba receptor, agonist and antinociceptive
5) Confidence 0.37 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 3037414 Disease Relevance 0 Pain Relevance 0.88
Acute (0.3 mg/kg or 0.5 mg/kg i.p.) and chronic nicotine, as well as morphine (15 mg/kg s.c.) in control mice decreased nipecotic acid-induced increase in extracellular GABA in the ventral tegmental area/substantia nigra (VTA/SN).
Negative_regulation (decreased) of Positive_regulation (increase) of GABA in substantia nigra associated with ventral tegmentum, gaba, substantia nigra, nicotine and morphine
6) Confidence 0.37 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18786163 Disease Relevance 0 Pain Relevance 1.61
The pharmacodynamic effects of vigabatrin (inhibition of central and peripheral GABA-T and increase of brain GABA levels) remain after the drug has been eliminated from plasma (Bolton et al 1989).
Negative_regulation (inhibition) of Positive_regulation (increase) of GABA in plasma associated with gaba
7) Confidence 0.36 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.25 Pain Relevance 0.39
To test whether the inhibitory action of GABA is specific to the retina, or common to other neural clock tissues, we applied 1 mM or 3 mM GABA to mouse mPer2Luc SCN explants.
Spec (whether) Negative_regulation (inhibitory) of Spec (whether) Positive_regulation (action) of GABA in neural associated with gaba
8) Confidence 0.34 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.76
Thus, the question posed by our data is whether a marked increase in fetal brain GABA affects cell migration, differentiation, and synaptogenesis or has an effect on the propensity for seizures?
Spec (whether) Negative_regulation (marked) of Spec (whether) Positive_regulation (increase) of GABA in brain associated with gaba and convulsion
9) Confidence 0.24 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.19 Pain Relevance 0.48
Luteinizing hormone releasing hormone (LHRH) neurons maintained in nasal explants decrease LHRH messenger ribonucleic acid levels after activation of GABA(A) receptors.
Negative_regulation (decrease) of Positive_regulation (activation) of GABA in neurons associated with gaba
10) Confidence 0.15 Published 1998 Journal Endocrinology Section Title Doc Link 9607779 Disease Relevance 0 Pain Relevance 0.41
Thus, the nicotine-induced analgesic effects in AS-ODN treated mice are likely to be attributed to the loss of tonic nAChR activation of inhibitory GABA interneurons.
Negative_regulation (loss) of Positive_regulation (activation) of GABA in interneurons associated with gaba, analgesic and nicotine
11) Confidence 0.07 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.53 Pain Relevance 1.44
Morphine reduced serotonin and increased dopamine in mussel tissues while reducing AChE activity and increasing GABA levels.
Negative_regulation (reducing) of Positive_regulation (increasing) of GABA associated with gaba, dopamine, serotonin and morphine
12) Confidence 0.03 Published 2010 Journal Comp. Biochem. Physiol. C Toxicol. Pharmacol. Section Abstract Doc Link 20398796 Disease Relevance 0.15 Pain Relevance 0.95

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