INT344763

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.11
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ALDH5A1) oxidoreductase activity (ALDH5A1)
Anatomy Link Frequency
epithelium 3
ALDH5A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 177 100.00 Very High Very High Very High
GABAergic 138 99.86 Very High Very High Very High
Nicotine 27 27.60 Quite Low
Glutamate 15 5.00 Very Low Very Low Very Low
Neurotransmitter 12 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
GABA receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 204 98.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 23.20 Low Low
Asthma 12 10.64 Low Low
Generalized Anxiety Disorder 15 5.00 Very Low Very Low Very Low
Metaplasia 9 5.00 Very Low Very Low Very Low
Hyperplasia 6 5.00 Very Low Very Low Very Low
Pulmonary Disease 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low
Adenocarcinoma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the GABA metabolism-related genes, both GABAT and ALDH5A1 were expressed in the large and small airway epithelium.
Gene_expression (expressed) of ALDH5A1 in epithelium associated with gaba
1) Confidence 0.55 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.42 Pain Relevance 0.53
The 13 GABAergic genes expressed in the large airway epithelium of nonsmokers included synthesis-related genes GAD67; receptors GABRB2, GABRB3, GABRE, GABRP, GABRR2, GABBR1, GABBR2; transport-related genes GAT-1,GAT-2, BGT-1 and metabolism-related genes GABA-T, ALDH5A1.
Gene_expression (expressed) of ALDH5A1 in epithelium associated with gaba and gabaergic
2) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.26 Pain Relevance 0.75
The 13 GABAergic genes expressed in the small airway epithelium of nonsmokers included synthesis-related genes GAD67; receptors GABRB2, GABRB3, GABRG1, GABRG3, GABRE, GABRP, GABRR2, GABBR1; transport-related genes GAT-1,GAT-2 and metabolism-related genes GABA-T, ALDH5A1.
Gene_expression (expressed) of ALDH5A1 in epithelium associated with gaba and gabaergic
3) Confidence 0.42 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.43 Pain Relevance 0.66

General Comments

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