INT3448

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Context Info
Confidence 0.69
First Reported 1975
Last Reported 2010
Negated 25
Speculated 28
Reported most in Abstract
Documents 521
Total Number 549
Disease Relevance 180.03
Pain Relevance 161.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
plasma 72
pituitary 22
blood 11
body 8
thyroid 5
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 1146 100.00 Very High Very High Very High
Sumatriptan 183 100.00 Very High Very High Very High
tolerance 175 100.00 Very High Very High Very High
dexamethasone 75 100.00 Very High Very High Very High
addiction 29 100.00 Very High Very High Very High
Glutamate 36 99.98 Very High Very High Very High
Somatostatin 1123 99.96 Very High Very High Very High
agonist 377 99.96 Very High Very High Very High
withdrawal 97 99.96 Very High Very High Very High
depression 144 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acromegaly 1289 100.00 Very High Very High Very High
Disease 781 100.00 Very High Very High Very High
Syndrome 718 100.00 Very High Very High Very High
Targeted Disruption 247 100.00 Very High Very High Very High
Impaired Glucose Tolerance 144 100.00 Very High Very High Very High
Multiple System Atrophy 100 100.00 Very High Very High Very High
Sleep Disorders 87 100.00 Very High Very High Very High
Hyperinsulinism 54 100.00 Very High Very High Very High
Hyperglycemia 18 100.00 Very High Very High Very High
Hypoglycemia 116 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increases in serum GH and lactate concentrations were significantly (P < 0.05) larger after the stimulation compared with the voluntary exercise.
Positive_regulation (Increases) of GH
1) Confidence 0.69 Published 2008 Journal J. Appl. Physiol. Section Abstract Doc Link 17975128 Disease Relevance 0.17 Pain Relevance 0
However, if a preconditioning was performed with sumatriptan, a 5-HT(1B/1D) agonist that stimulates GH and inhibits cortisol secretion, a significant increase of GH and decrease of cortisol plasma concentrations were found after placebo administration, although opposite verbal suggestions were given.
Positive_regulation (increase) of GH in plasma associated with sumatriptan and agonist
2) Confidence 0.69 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764120 Disease Relevance 0.52 Pain Relevance 0.60
However, if a preconditioning was performed with sumatriptan, a 5-HT(1B/1D) agonist that stimulates GH and inhibits cortisol secretion, a significant increase of GH and decrease of cortisol plasma concentrations were found after placebo administration, although opposite verbal suggestions were given.
Positive_regulation (stimulates) of GH in plasma associated with sumatriptan and agonist
3) Confidence 0.69 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764120 Disease Relevance 0.52 Pain Relevance 0.59
In acute administration, the drug provokes a significant increase in the plasma concentrations of growth hormone (GH).
Positive_regulation (increase) of GH in plasma
4) Confidence 0.69 Published 1982 Journal Diabete Metab Section Abstract Doc Link 7160519 Disease Relevance 0.43 Pain Relevance 0.52
In acute administration, the drug provokes a significant increase in the plasma concentrations of growth hormone (GH).
Positive_regulation (increase) of growth hormone in plasma
5) Confidence 0.69 Published 1982 Journal Diabete Metab Section Abstract Doc Link 7160519 Disease Relevance 0.43 Pain Relevance 0.51
Clonidine did not increase GH levels significantly over time compared with placebo.
Neg (not) Positive_regulation (increase) of GH associated with clonidine
6) Confidence 0.69 Published 1991 Journal Eur Arch Psychiatry Clin Neurosci Section Abstract Doc Link 1657199 Disease Relevance 0.25 Pain Relevance 0.57
The growth hormone (GH) response to clonidine was initially impaired, but increased significantly after one week of treatment.
Positive_regulation (increased) of growth hormone associated with clonidine
7) Confidence 0.69 Published 1982 Journal Br J Psychiatry Section Abstract Doc Link 6293637 Disease Relevance 0.18 Pain Relevance 0.53
The growth hormone (GH) response to clonidine was initially impaired, but increased significantly after one week of treatment.
Positive_regulation (increased) of GH associated with clonidine
8) Confidence 0.69 Published 1982 Journal Br J Psychiatry Section Abstract Doc Link 6293637 Disease Relevance 0.18 Pain Relevance 0.52
In two children with short stature without endocrinological disturb, there was a partial failure to increase GH in response to clonidine.
Spec (partial) Positive_regulation (increase) of GH associated with growth problems and clonidine
9) Confidence 0.69 Published 1981 Journal An. Esp. Pediatr. Section Abstract Doc Link 7283286 Disease Relevance 0.27 Pain Relevance 0.44
Significant GH increase was observed, as other authors have reported.
Positive_regulation (increase) of GH
10) Confidence 0.69 Published 1981 Journal An. Esp. Pediatr. Section Abstract Doc Link 7283286 Disease Relevance 0.28 Pain Relevance 0.41
Morphine caused an elevation of growth hormone in both acromegalics and normal subjects (p < 0.05).
Positive_regulation (elevation) of growth hormone associated with morphine
11) Confidence 0.68 Published 2005 Journal Horm. Metab. Res. Section Abstract Doc Link 16034714 Disease Relevance 0.41 Pain Relevance 0.64
We have treated with clonidine (0.100 mg/m2 for six months) all patients and there were significant results: higher values of basal GH and increase in the response to the clonidine test also in patients hyporesponders before treatment.
Positive_regulation (increase) of GH associated with clonidine
12) Confidence 0.67 Published 1990 Journal G Clin Med Section Abstract Doc Link 2279627 Disease Relevance 0.07 Pain Relevance 0.37
Arginine-stimulated GH peak levels correlated negatively with indices of adiposity and age [intraabdominal fat: r = -0.72, P < 0.001; W/H-ratio: r = -0.58, P < 0.001; age: r = -0.54, P < 0.001], and positively with VO2-max [r = 0.60, P < 0.001].
Positive_regulation (stimulated) of GH in fat
13) Confidence 0.67 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8964853 Disease Relevance 0.46 Pain Relevance 0.36
In the oral glucose tolerance test, paradoxic elevation of GH subsided after treatment.
Positive_regulation (elevation) of GH associated with tolerance and impaired glucose tolerance
14) Confidence 0.66 Published 1992 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 1358345 Disease Relevance 0.53 Pain Relevance 0.24
Sumatriptan induced a significant (P<0.01) increase in GH concentrations both in migraine patients and healthy controls.
Positive_regulation (increase) of GH associated with sumatriptan and migraine
15) Confidence 0.66 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10999671 Disease Relevance 0.26 Pain Relevance 0.77
Preclonidine stress-related GH elevations were observed, to the greatest degree in anxious subjects.
Positive_regulation (elevations) of GH
16) Confidence 0.66 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15576065 Disease Relevance 0 Pain Relevance 0
In contrast, no significant GH elevation was seen in GH-deficient children (1.3 +/- 0.4 micrograms/l).
Neg (no) Positive_regulation (elevation) of GH
17) Confidence 0.65 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.40
Although no significant GH release was observed after dexamethasone or clonidine in GH deficiency, an increase in GH after GH-releasing hormone was seen (6.1 +/- 1.9 micrograms/l).
Positive_regulation (increase) of GH associated with dexamethasone and clonidine
18) Confidence 0.65 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.51
There was a significant GH increase at 120, 150 and 180 min in short normal children (maximal value: 18.9 +/- 2.1 micrograms/l; mean +/- EP), compared to placebo administration.
Positive_regulation (increase) of GH
19) Confidence 0.65 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.33
This study compared the GH responses induced by a moderate-intensity exercise bout during treatment with placebo (Plac), the opioid receptor antagonist naltrexone (Nalt), the indirect cholinergic agonist pyridostigmine (PD), or a combination of the two drugs (P + N).
Positive_regulation (induced) of GH associated with antagonist, agonist and opioid receptor
20) Confidence 0.65 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 8226493 Disease Relevance 0 Pain Relevance 0.31

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