INT344866

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mapt) cytoskeleton (Mapt) nucleus (Mapt)
enzyme binding (Mapt) cytoplasm (Mapt)
Anatomy Link Frequency
cleavage 2
Mapt (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 82.96 Quite High
Central nervous system 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Tauopathy 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low
Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding of endopeptidase-like cleavage of Tau, the insensitivity of the reaction to PSA inhibitors, together with the sensitivity of the reaction to the metal chelator o-phenanthroline suggest either contamination of the hPSASf preparation with a metallo-endopeptidase that cleaves Tau or that the cleavage of Tau by hPSASf proceeds through a novel mechanism.
Positive_regulation (cleaves) of Protein_catabolism (cleavage) of Tau in cleavage
1) Confidence 0.49 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.08

General Comments

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