INT344867

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Context Info
Confidence 0.86
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.25
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mapt) cytoskeleton (Mapt) nucleus (Mapt)
enzyme binding (Mapt) cytoplasm (Mapt)
Anatomy Link Frequency
cleavage 4
internal 1
Mapt (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 14 92.72 High High
Central nervous system 7 10.52 Low Low
imagery 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tauopathy 14 95.68 Very High Very High Very High
Shock 7 94.24 High High
Neurodegenerative Disease 14 61.92 Quite High
Disease 14 32.96 Quite Low
Sprains And Strains 7 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether PSA might facilitate cleavage of Tau in a cellular context, we transduced HEK 293 cells expressing a tetracycline-inducible human 2N4R Tau with a lentivirus expressing PSA.
Protein_catabolism (cleavage) of Tau in cleavage
1) Confidence 0.86 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.09 Pain Relevance 0
The finding of endopeptidase-like cleavage of Tau, the insensitivity of the reaction to PSA inhibitors, together with the sensitivity of the reaction to the metal chelator o-phenanthroline suggest either contamination of the hPSASf preparation with a metallo-endopeptidase that cleaves Tau or that the cleavage of Tau by hPSASf proceeds through a novel mechanism.
Protein_catabolism (cleavage) of Tau in cleavage
2) Confidence 0.86 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.08
The present study was designed to further investigate how PSA cleaves Tau; however, the results of these studies led us to conclude that Tau is not directly cleaved by PSA or by the closely related aminopeptidase, aminopeptidase N.


Neg (not) Protein_catabolism (cleaved) of Tau
3) Confidence 0.64 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.06 Pain Relevance 0
It was recently reported that Tau can be degraded by an aminopeptidase known as the puromycin sensitive aminopeptidase (PSA).
Protein_catabolism (degraded) of Tau
4) Confidence 0.64 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2988785 Disease Relevance 0.10 Pain Relevance 0
This finding shows that Tau cleavage was internal, not expected for an aminopeptidase.
Protein_catabolism (cleavage) of Tau in internal
5) Confidence 0.64 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0
The finding of endopeptidase-like cleavage of Tau, the insensitivity of the reaction to PSA inhibitors, together with the sensitivity of the reaction to the metal chelator o-phenanthroline suggest either contamination of the hPSASf preparation with a metallo-endopeptidase that cleaves Tau or that the cleavage of Tau by hPSASf proceeds through a novel mechanism.
Protein_catabolism (cleavage) of Tau in cleavage
6) Confidence 0.64 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.09
When tested in a cellular context we again failed to see a PSA dependent cleavage of Tau.
Protein_catabolism (cleavage) of Tau in cleavage
7) Confidence 0.64 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0

General Comments

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