INT34489

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.20
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CAPRIN1) cytosol (CAPRIN1) RNA binding (CAPRIN1)
cytoplasm (CAPRIN1)
Anatomy Link Frequency
eosinophil 2
polymorphonuclear leukocytes 2
myocytes 1
monocytes 1
CAPRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 99.40 Very High Very High Very High
Inflammation 14 99.26 Very High Very High Very High
antagonist 3 77.92 Quite High
imagery 9 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
c fibre 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 19 99.28 Very High Very High Very High
Asthma 66 96.08 Very High Very High Very High
Status Asthmaticus 3 74.56 Quite High
Rhinitis 12 44.16 Quite Low
Pressure And Volume Under Development 3 30.92 Quite Low
Disease 3 25.96 Quite Low
Adhesions 9 5.00 Very Low Very Low Very Low
Pulmonary Disease 9 5.00 Very Low Very Low Very Low
Nicotine Addiction 6 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It displays a stabilizing effect on erythrocyte membranes which appears related to its high affinity for membranes in general, and it inhibits the respiratory burst of stimulated human monocytes and granule enzyme release by human neutrophils.
Localization (release) of granule enzyme in monocytes
1) Confidence 0.70 Published 1985 Journal Int J Tissue React Section Abstract Doc Link 4044146 Disease Relevance 0.07 Pain Relevance 0.40
But, in none of these studies was an analysis of the MBP performed such that the granule protein localization could be differentiated between intracellular and extracellular deposition, nor was a precise localization of the eosinophils in relative distance and distribution to myocytes and airway neurons established.
Localization (localization) of granule protein in myocytes
2) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.23 Pain Relevance 0.03
However, these prior investigations rest on the hypothesis that cationic peptides delivered to the airway luminal surface mimic in vivo eosinophil granule protein release and that granule protein release never occurs within the airway wall.
Localization (release) of granule protein in eosinophil
3) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.27 Pain Relevance 0.04
However, these prior investigations rest on the hypothesis that cationic peptides delivered to the airway luminal surface mimic in vivo eosinophil granule protein release and that granule protein release never occurs within the airway wall.
Localization (release) of granule protein in eosinophil
4) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.27 Pain Relevance 0.04
Inhibition by nonsteroidal anti-inflammatory drugs of superoxide production and granule enzyme release by polymorphonuclear leukocytes stimulated with immune complexes or formyl-methionyl-leucyl-phenylalanine.
Localization (release) of granule enzyme in polymorphonuclear leukocytes associated with inflammation and cinod
5) Confidence 0.03 Published 1987 Journal Biochem. Pharmacol. Section Title Doc Link 3038127 Disease Relevance 0.19 Pain Relevance 0.15
The effects of nonsteroidal anti-inflammatory agents on superoxide production and granule enzyme release by human polymorphonuclear leukocytes stimulated with either formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe] or immune complexes were investigated.
Localization (release) of granule enzyme in polymorphonuclear leukocytes associated with inflammation
6) Confidence 0.03 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3038127 Disease Relevance 0.17 Pain Relevance 0.12

General Comments

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