INT34490

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Context Info
Confidence 0.01
First Reported 1987
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.08
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GBE1) generation of precursor metabolites and energy (GBE1) small molecule metabolic process (GBE1)
transferase activity, transferring glycosyl groups (GBE1) carbohydrate metabolic process (GBE1)
Anatomy Link Frequency
plasma 2
neutrophils 2
GBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 99.84 Very High Very High Very High
cytokine 1 98.72 Very High Very High Very High
Inflammation 74 98.68 Very High Very High Very High
Bile 1 94.36 High High
Cholecystokinin 4 89.44 High High
cINOD 2 75.00 Quite High
corticosteroid 26 67.08 Quite High
headache 1 63.36 Quite High
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 1 99.84 Very High Very High Very High
INFLAMMATION 71 98.68 Very High Very High Very High
Exocrine Pancreatic Insufficiency 1 84.88 Quite High
Pulmonary Disease 52 83.52 Quite High
Nicotine Addiction 14 77.00 Quite High
Vomiting 1 64.00 Quite High
Headache 1 63.36 Quite High
Diarrhoea 1 62.24 Quite High
Disease 37 50.00 Quite Low
Asthma 99 47.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quinacrine inhibited superoxide production equally well with both stimuli but inhibited enzyme release only with fMet-Leu-Phe.
Negative_regulation (inhibited) of Localization (release) of enzyme
1) Confidence 0.01 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3038127 Disease Relevance 0.18 Pain Relevance 0.16
The severely reduced enzyme secretion in chronic pancreatitis did not influence the basal or oleic acid-stimulated concentrations of the hormones in plasma.
Negative_regulation (reduced) of Localization (secretion) of enzyme in plasma associated with chronic pancreatitis
2) Confidence 0.01 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.18 Pain Relevance 0.30
PDE4 inhibitors have a variety of anti-inflammatory effects on neutrophils, including inhibition of chemotaxis [73], suppression of proteolytic enzyme release, inhibition of proinflammatory cytokine release, particularly IL-8 and leukotriene B4 [74,75], and inhibition of CD11b integrin expression [73].
Negative_regulation (suppression) of Localization (release) of enzyme in neutrophils associated with inflammation and cytokine
3) Confidence 0.00 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873624 Disease Relevance 1.71 Pain Relevance 0.56

General Comments

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