INT344931

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) plasma membrane (Comt) cytoplasm (Comt)
Comt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 2 100.00 Very High Very High Very High
Dopamine 18 99.98 Very High Very High Very High
Nucleus accumbens 2 88.68 High High
Neurotransmitter 8 84.72 Quite High
alcohol 60 50.00 Quite Low
positron emission tomography 2 35.04 Quite Low
imagery 10 26.60 Quite Low
Anterior cingulate 2 14.32 Low Low
GABAergic 10 5.00 Very Low Very Low Very Low
amygdala 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 34 5.00 Very Low Very Low Very Low
Drug Dependence 10 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low
Aggression 4 5.00 Very Low Very Low Very Low
Conduct Disorder 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Substance Withdrawal Syndrome 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activity of the dopamine degrading enzyme catechol-O-methyltransferase (COMT) appears to increase in mid-adulthood (after age 30) based on post mortem studies (Tunbridge et al. 2007), but does not differ between infants, adolescents, and young adults.
Spec (appears) Positive_regulation (increase) of Protein_catabolism (degrading) of COMT associated with catechol-o-methyltransferase and dopamine
1) Confidence 0.49 Published 2010 Journal Neuropsychol Rev Section Body Doc Link PMC2988999 Disease Relevance 0 Pain Relevance 0.38
Activity of the dopamine degrading enzyme catechol-O-methyltransferase (COMT) appears to increase in mid-adulthood (after age 30) based on post mortem studies (Tunbridge et al. 2007), but does not differ between infants, adolescents, and young adults.
Spec (appears) Positive_regulation (increase) of Protein_catabolism (degrading) of enzyme catechol-O-methyltransferase associated with catechol-o-methyltransferase and dopamine
2) Confidence 0.07 Published 2010 Journal Neuropsychol Rev Section Body Doc Link PMC2988999 Disease Relevance 0 Pain Relevance 0.38

General Comments

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