INT344976

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.13
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dkk1) extracellular region (Dkk1) plasma membrane (Dkk1)
Anatomy Link Frequency
joint 2
Dkk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 70 99.04 Very High Very High Very High
antagonist 2 89.08 High High
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteophyte 6 99.80 Very High Very High Very High
Osteoarthritis 70 99.04 Very High Very High Very High
Disease 16 97.92 Very High Very High Very High
Arthropathy 6 83.60 Quite High
Knee Osteoarthritis 3 50.00 Quite Low
Osteoporosis 1 45.88 Quite Low
Obesity 7 5.00 Very Low Very Low Very Low
Sclerosis 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, decreased Dkk-1 levels tend to be essential for osteophyte formation, suggesting that Wnt signaling is a critical initiator for bone formation in the joint.
Positive_regulation (essential) of Negative_regulation (decreased) of Dkk-1 in joint associated with osteophyte
1) Confidence 0.49 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.13 Pain Relevance 0.33

General Comments

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