INT34500

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Context Info
Confidence 0.58
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 2.59
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADRB3) aging (ADRB3) plasma membrane (ADRB3)
nucleus (ADRB3) carbohydrate metabolic process (ADRB3) signal transducer activity (ADRB3)
Anatomy Link Frequency
myometrium 2
outflow 1
neuron 1
fat cell 1
ADRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 65 99.96 Very High Very High Very High
potassium channel 2 97.76 Very High Very High Very High
Catecholamine 1 95.84 Very High Very High Very High
Clonidine 5 94.72 High High
Dopamine 2 92.60 High High
tolerance 1 92.44 High High
cytokine 5 89.52 High High
antagonist 25 87.60 High High
anesthesia 4 84.12 Quite High
epidural 2 83.68 Quite High
Disease Link Frequency Relevance Heat
Overactive Bladder 12 99.92 Very High Very High Very High
Aging 3 99.82 Very High Very High Very High
Thyroid Disease 6 99.52 Very High Very High Very High
Obesity 15 99.10 Very High Very High Very High
Congenital Anomalies 1 98.72 Very High Very High Very High
Pressure Volume 2 Under Development 1 96.64 Very High Very High Very High
Bladder Disease 1 95.68 Very High Very High Very High
Dysmenorrhea 7 80.88 Quite High
Necrosis 2 75.00 Quite High
Cancer 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present functional study provides the first evidence that relaxation of the ferret detrusor by beta-adrenoceptor activation is mediated mainly via the beta(3)-adrenoceptor, as in the human detrusor.
Positive_regulation (activation) of beta-adrenoceptor associated with overactive bladder
1) Confidence 0.58 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10969156 Disease Relevance 0.25 Pain Relevance 0.06
The FPEs and PE had positive chronotropic and inotropic effects in isolated guinea-pig atria apparently through the activation of a beta-adrenoceptor, since pindolol blocked the response while prazosin did not. 6-FPE appeared less active than the other PEs in atria.
Positive_regulation (activation) of beta-adrenoceptor
2) Confidence 0.55 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3038567 Disease Relevance 0.17 Pain Relevance 0.21
Binding competition studies, transcripts and protein analysis were then performed to determine whether any changes in the number of ADRB2 and ADRB3 binding sites and in the transcript and protein expression might explain the observed change in the contractile response between non-pregnant and pregnant myometrium to ADRB2 and ADRB3 agonists.
Positive_regulation (response) of ADRB3 in myometrium associated with agonist
3) Confidence 0.50 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.05
Stimulation of ADRB3 relaxes pregnant myometrial strips probably by opening potassium channels [55].
Positive_regulation (Stimulation) of ADRB3 associated with potassium channel
4) Confidence 0.50 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.08 Pain Relevance 0.24
Adipocytes are a potential source for SST. beta3-AR activation may be a promising approach to reduce enteric neuron hyperexcitability.
Positive_regulation (activation) of beta3-AR in neuron
5) Confidence 0.47 Published 2010 Journal Gastroenterology Section Body Doc Link 19786030 Disease Relevance 0 Pain Relevance 0
Densitometric analysis of the RT-PCR experiments indicated a slight decrease in the signal for ADRB2 mRNA (-27.4%) in near-term myometrium comparatively to non-pregnant tissue whereas the signal for ADRB3 mRNA was increased in pregnant myometrium (+66.3%).
Positive_regulation (increased) of ADRB3 in myometrium
6) Confidence 0.47 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.10
Although there was a moderate increase in the beta-adrenoceptor density in hyperthyroidism, the most important abnormality, namely the increased responsiveness to the catecholamines, seems to be located beyond the receptor level.
Positive_regulation (increase) of beta-adrenoceptor associated with catecholamine and thyroid disease
7) Confidence 0.42 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3734033 Disease Relevance 0.91 Pain Relevance 0.24
We speculate that the down-regulation of beta-adrenoceptor induced by the sympathomimetic action of amphetamine, might be a major cause of refractory hypotension.
Positive_regulation (induced) of beta-adrenoceptor associated with pressure volume 2 under development
8) Confidence 0.41 Published 2001 Journal Masui Section Abstract Doc Link 11758335 Disease Relevance 0.17 Pain Relevance 0.36
In fat cell membranes, 2-FPE was more potent than PE in stimulating adenylate cyclase via a beta-adrenoceptor, while 4-FPE and 6-FPE were inactive.
Positive_regulation (stimulating) of beta-adrenoceptor in fat cell associated with obesity
9) Confidence 0.40 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3038567 Disease Relevance 0.19 Pain Relevance 0.23
Our results show that activation of the beta-adrenergic receptor inhibits myocardial production of TNF-alpha.
Positive_regulation (activation) of beta-adrenergic receptor
10) Confidence 0.26 Published 2000 Journal Am Surg Section Abstract Doc Link 11261622 Disease Relevance 0.15 Pain Relevance 0.09
Recent information on the alpha-adrenoceptor, beta-adrenoceptor (beta 3), and muscarinic receptor subtypes of the human detrusor and outflow region can be the basis for the development of compounds with effect on bladder overactivity and with improved tolerance.
Positive_regulation (information) of beta-adrenoceptor in outflow associated with tolerance and overactive bladder
11) Confidence 0.20 Published 1999 Journal Exp. Physiol. Section Abstract Doc Link 10081718 Disease Relevance 0.47 Pain Relevance 0.49
Normal aging impairs upregulation of the beta-adrenergic but not the alpha-adrenergic response: aging and adrenergic upregulation.
Positive_regulation (upregulation) of beta-adrenergic associated with aging
12) Confidence 0.01 Published 2006 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 17086093 Disease Relevance 0.20 Pain Relevance 0.09

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