INT345013

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.49
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSN) extracellular space (GSN) vesicle-mediated transport (GSN)
aging (GSN) extracellular region (GSN) protein complex (GSN)
Anatomy Link Frequency
blood 1
CSF 1
GSN (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 177 99.08 Very High Very High Very High
headache 3 92.88 High High
cytokine 3 37.84 Quite Low
imagery 7 28.40 Quite Low
Inflammation 12 25.12 Quite Low
intrathecal 3 19.28 Low Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
Abeta 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 180 99.08 Very High Very High Very High
Familial Dysautonomia 242 98.84 Very High Very High Very High
Headache 3 92.88 High High
Apoptosis 4 91.48 High High
Paralysis 3 90.76 High High
Disease 61 89.56 High High
INFLAMMATION 12 25.12 Quite Low
Rheumatoid Arthritis 17 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Adult Respiratory Distress Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, 2 genes, PMEPA1 and GSN (encoding TMEPAI and gelsolin, respectively), involved in cell growth and cytoskeleton organization, respectively, were dysregulated in both the IKBKAP RNAi and FD iPS cell studies.
Regulation (dysregulated) of GSN associated with familial dysautonomia
1) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.59 Pain Relevance 0
However, lowered gelsolin concentration in CSF samples did not reach statistical significance when compared to its concentration in the control group.
Regulation (concentration) of gelsolin
2) Confidence 0.26 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.88 Pain Relevance 0.40
We measured GSN and DBP concentrations in blood and CSF obtained from patients diagnosed with MS (n = 56) in comparison to a control group (n = 20) that includes patients diagnosed with conditions such as idiopathic cephalgia (n = 11), idiopathic (Bell's) facial nerve palsy (n = 7) and ischialgia due to discopathy (n = 2).
Regulation (concentrations) of GSN in blood associated with multiple sclerosis, headache and paralysis
3) Confidence 0.23 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC2989318 Disease Relevance 0.71 Pain Relevance 0.36
Interestingly, 2 genes, PMEPA1 and GSN (encoding TMEPAI and gelsolin, respectively), involved in cell growth and cytoskeleton organization, respectively, were dysregulated in both the IKBKAP RNAi and FD iPS cell studies.
Regulation (dysregulated) of gelsolin associated with familial dysautonomia
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.59 Pain Relevance 0
We measured GSN and DBP concentrations in blood and CSF obtained from patients diagnosed with MS (n = 56) in comparison to a control group (n = 20) that includes patients diagnosed with conditions such as idiopathic cephalgia (n = 11), idiopathic (Bell's) facial nerve palsy (n = 7) and ischialgia due to discopathy (n = 2).
Regulation (concentrations) of GSN in CSF associated with multiple sclerosis, headache and paralysis
5) Confidence 0.08 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC2989318 Disease Relevance 0.71 Pain Relevance 0.36

General Comments

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