INT345015

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.58
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSN) extracellular space (GSN) vesicle-mediated transport (GSN)
aging (GSN) extracellular region (GSN) protein complex (GSN)
GSN (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 236 97.52 Very High Very High Very High
rheumatoid arthritis 20 93.28 High High
Inflammation 16 89.72 High High
Abeta 4 84.96 Quite High
intrathecal 4 67.80 Quite High
cytokine 4 58.40 Quite High
Central nervous system 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 240 97.52 Very High Very High Very High
Disease 52 95.68 Very High Very High Very High
Rheumatoid Arthritis 20 93.28 High High
INFLAMMATION 16 89.72 High High
Adult Respiratory Distress Syndrome 8 21.40 Low Low
Neurodegenerative Disease 8 8.32 Low Low
Lumbar Puncture Related Headaches 8 5.00 Very Low Very Low Very Low
Injury 8 5.00 Very Low Very Low Very Low
Sepsis 8 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The QAlb values indicate lack of CSF-barrier dysfunction in MS subjects included in our study, and it is very likely that the depletion of GSN and DBP from CSF that occurs as these proteins bind actin cannot be compensated for by an increased production or transport of gelsolin.
Positive_regulation (increased) of Gene_expression (production) of gelsolin associated with multiple sclerosis
1) Confidence 0.49 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.75 Pain Relevance 0.37
On the other hand, in recent studies overexpression of gelsolin restored the impaired mitochondrial activity associated with CNS degeneration in the course of Alzheimer's disease (AD).
Positive_regulation (overexpression) of Gene_expression (overexpression) of gelsolin associated with disease
2) Confidence 0.45 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 1.54 Pain Relevance 0.53
Here we report that average gelsolin concentrations in CSF collected from patients diagnosed with MS was lower (2.9 ± 1.8 versus 4.1 ± 1.7 ?
Positive_regulation (average) of Gene_expression (average) of gelsolin associated with multiple sclerosis
3) Confidence 0.42 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.78 Pain Relevance 0.35
At the same time, these results are in agreement with the sequestration hypothesis that was proposed as a mechanism of actin-mediated gelsolin depletion [34].
Positive_regulation (mediated) of Gene_expression (depletion) of gelsolin
4) Confidence 0.42 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.51 Pain Relevance 0.26

General Comments

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