INT345099

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Lpar4) signal transduction (Lpar4) plasma membrane (Lpar4)
signal transducer activity (Lpar4)
Anatomy Link Frequency
neurite 2
Lpar4 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 15 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 1 97.48 Very High Very High Very High
Shock 1 95.24 Very High Very High Very High
Targeted Disruption 15 59.60 Quite High
Cancer 24 5.00 Very Low Very Low Very Low
Ovarian Cancer 16 5.00 Very Low Very Low Very Low
Apoptosis 15 5.00 Very Low Very Low Very Low
Metastasis 10 5.00 Very Low Very Low Very Low
Neuropathic Pain 10 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The brain expresses relatively high levels of LPA4; and it has been shown, using heterologous expression in B103 neuroblastoma cells, to cause LPA-dependent growth cone collapse and neurite retraction through G12/13-RhoA-Rho-associated kinase (ROCK) activation (Lee et al., 2007).
Positive_regulation (levels) of Gene_expression (expresses) of LPA4 in neurite associated with neuroblastoma and shock
1) Confidence 0.21 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.25 Pain Relevance 0

General Comments

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