INT345107

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar5) signal transducer activity (Lpar5)
Anatomy Link Frequency
platelets 1
Lpar5 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 98.20 Very High Very High Very High
antagonist 30 96.92 Very High Very High Very High
Inflammation 2 61.80 Quite High
cva 2 30.08 Quite Low
fibrosis 18 6.72 Low Low
Neuropathic pain 16 5.00 Very Low Very Low Very Low
dorsal root ganglion 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 4 73.96 Quite High
Cancer 48 68.72 Quite High
Atherosclerosis 4 67.56 Quite High
Disease 14 65.04 Quite High
INFLAMMATION 4 61.80 Quite High
Apoptosis 30 60.16 Quite High
Myocardial Infarction 4 46.40 Quite Low
Age-related Macular Degeneration 2 39.88 Quite Low
Atherosclerotic Plaque 2 39.12 Quite Low
Thrombosis 8 36.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, with the exception of LPA5, the alkyl analogues of LPA are less potent agonists of the remaining LPA GPCR; however, 1-O-alkyl glycerophosphate is considerably more potent than LPA at PPAR?
Neg (exception) Transcription (exception) of LPA5 associated with agonist
1) Confidence 0.35 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.46 Pain Relevance 0.15
LPA4 and LPA5 transcripts are both abundant in human platelets mixed from multiple donors (Amisten et al., 2008).
Transcription (transcripts) of LPA5 in platelets
2) Confidence 0.35 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0.09

General Comments

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