INT345109

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.78
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr87) plasma membrane (Gpr87) signal transducer activity (Gpr87)
Anatomy Link Frequency
urinary bladder 1
plasma 1
Gpr87 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 60 90.28 High High
Neuropathic pain 32 68.00 Quite High
Pain 16 63.56 Quite High
dorsal root ganglion 16 51.40 Quite High
allodynia 8 41.84 Quite Low
chung model 4 37.24 Quite Low
Action potential 8 30.76 Quite Low
Dorsal horn 4 20.64 Low Low
tail-flick 4 15.32 Low Low
agonist 60 13.16 Low Low
Disease Link Frequency Relevance Heat
Skin Cancer 12 99.60 Very High Very High Very High
Adenocarcinoma 4 98.36 Very High Very High Very High
Carcinoma 4 97.04 Very High Very High Very High
Hypotrichosis 12 76.80 Quite High
Neuropathic Pain 40 68.00 Quite High
Pain 16 63.56 Quite High
Nociception 8 59.92 Quite High
Disease 28 59.76 Quite High
Ganglion Cysts 20 51.40 Quite High
Targeted Disruption 60 35.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of GPR87 alone is difficult, suggesting that the posttranslational processing of this receptor might be complex and that attaching G16 to the putative receptor increases plasma membrane expression of the fusion construct (Dr Norihisa Fujita – personal communication).
Gene_expression (Expression) of GPR87 in plasma
1) Confidence 0.26 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.24 Pain Relevance 0.19
In chronological order based on the first publication, these include the GPR87 (Tabata et al., 2007; Wetter et al., 2009), P2Y5 (Pasternack et al., 2008; Shimomura et al., 2008), P2Y10 (Murakami et al., 2008) and GPR35 (Oka et al., 2010) gene products.
Gene_expression (products) of GPR87
2) Confidence 0.23 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0
GPR87 is under the transcriptional regulation of p53; shows a very high expression level in squamous cell carcinomas, lung adenocarcinomas and transitional carcinomas of the urinary bladder and is involved in promoting cell survival and proliferation (Glatt et al., 2008; Gugger et al., 2008; Zhang et al., 2009b).
Gene_expression (expression) of GPR87 in urinary bladder associated with adenocarcinoma, carcinoma and skin cancer
3) Confidence 0.23 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.43 Pain Relevance 0.05
GPR87-G16-transfected CHO cells mobilize Ca2+ in response to LPA with an EC50 of 36 nM.
Gene_expression (transfected) of GPR87
4) Confidence 0.20 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.11 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox