INT345113

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar3) plasma membrane (Lpar3) signal transducer activity (Lpar3)
Anatomy Link Frequency
embryo 1
Lpar3 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 30 72.28 Quite High
agonist 30 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
Neuropathic pain 16 5.00 Very Low Very Low Very Low
dorsal root ganglion 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 2 99.84 Very High Very High Very High
Targeted Disruption 30 94.04 High High
Male Infertility 4 91.84 High High
Apoptosis 30 88.24 High High
Aging 4 84.92 Quite High
Placenta Previa 2 80.80 Quite High
Infertility 2 75.68 Quite High
Cancer 48 56.04 Quite High
Hypertension 2 55.84 Quite High
Metastasis 20 55.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LPA3 receptor, which is up-regulated by progesterone and down-regulated by oestrogen, is required for embryo implantation and affects embryo spacing in the womb (Ye et al., 2005; Hama et al., 2007).
Regulation (affects) of LPA3 receptor in embryo
1) Confidence 0.22 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.27 Pain Relevance 0.09
There is a wealth of evidence that links LPA, LPA3 and LPA1 to the regulation of prostate cancer cells (Qi et al., 1998; Prenzel et al., 1999; Im et al., 2000; Daaka, 2002; Guo et al., 2006; Hwang et al., 2006).
Regulation (regulation) of LPA3 associated with reprotox - general 1
2) Confidence 0.06 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.77 Pain Relevance 0.10

General Comments

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