INT345123

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.76
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar5) signal transducer activity (Lpar5)
Anatomy Link Frequency
neurons 2
dorsal root ganglia 2
brain 1
spleen 1
small intestine 1
Lpar5 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 93 99.68 Very High Very High Very High
Neuropathic pain 90 98.00 Very High Very High Very High
allodynia 25 96.72 Very High Very High Very High
c fibre 11 96.20 Very High Very High Very High
agonist 150 95.20 Very High Very High Very High
Kinase C 37 94.88 High High
Pain 49 94.80 High High
chung model 10 92.12 High High
antagonist 156 90.32 High High
Action potential 20 85.64 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 10 99.92 Very High Very High Very High
Ganglion Cysts 104 99.68 Very High Very High Very High
Neuropathic Pain 116 98.00 Very High Very High Very High
Targeted Disruption 151 95.80 Very High Very High Very High
Pain 51 94.80 High High
Bone Cancer 43 90.28 High High
Nociception 25 73.28 Quite High
Congenital Anomalies 20 69.12 Quite High
Cancer 273 66.64 Quite High
Shock 10 48.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPA5-lacZ reporter gene-expressing mice showed the strongest expression in cell bodies of dorsal root ganglion cells that extend C-fibres (sensory nerves conveying pain signals) but not in those neurons with A?
Gene_expression (expressing) of LPA5 in neurons associated with ganglion cysts, pain, c fibre and dorsal root ganglion
1) Confidence 0.39 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.65 Pain Relevance 0.54
Intestinal CD8+ lymphocytes, as well as B cells, show abundant expression of LPA5 (Kotarsky et al., 2006), suggesting an immunoregulatory role.
Gene_expression (expression) of LPA5 in B cells
2) Confidence 0.39 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.15 Pain Relevance 0
In another study, LPA5 protein was detected using immunohistology in dorsal root ganglion cells of mice and humans (Oh da et al., 2008).
Gene_expression (detected) of LPA5 protein in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
3) Confidence 0.34 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 1.06 Pain Relevance 0.96
LPA5 is present in the heart, placenta, brain, dorsal root ganglia, small intestine and spleen.
Gene_expression (present) of LPA5 in brain
4) Confidence 0.30 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.16 Pain Relevance 0
The ligand preference of LPA5 is 1-O-alkyl glycerophosphate 18:1 ?
Gene_expression (preference) of LPA5
5) Confidence 0.29 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.13 Pain Relevance 0.03
LPA5 is present in the heart, placenta, brain, dorsal root ganglia, small intestine and spleen.
Gene_expression (present) of LPA5 in small intestine
6) Confidence 0.10 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.16 Pain Relevance 0
LPA5 is present in the heart, placenta, brain, dorsal root ganglia, small intestine and spleen.
Gene_expression (present) of LPA5 in placenta
7) Confidence 0.10 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.16 Pain Relevance 0
LPA5 is present in the heart, placenta, brain, dorsal root ganglia, small intestine and spleen.
Gene_expression (present) of LPA5 in heart
8) Confidence 0.10 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.16 Pain Relevance 0
LPA5 is present in the heart, placenta, brain, dorsal root ganglia, small intestine and spleen.
Gene_expression (present) of LPA5 in spleen
9) Confidence 0.10 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.16 Pain Relevance 0
LPA5 is present in the heart, placenta, brain, dorsal root ganglia, small intestine and spleen.
Gene_expression (present) of LPA5 in dorsal root ganglia
10) Confidence 0.10 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.16 Pain Relevance 0
Among the six LPA receptors, LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6, LPA1 receptor is the main subtype expressed in the DRG neurons [11].
Gene_expression (expressed) of LPA5 in neurons associated with dorsal root ganglion
11) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.79 Pain Relevance 0.87

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox