INT345127

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.53
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry10) plasma membrane (P2ry10) signal transducer activity (P2ry10)
Anatomy Link Frequency
platelets 1
P2ry10 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 75 80.96 Quite High
alcohol 10 31.76 Quite Low
antagonist 75 25.48 Quite Low
fibrosis 45 5.00 Very Low Very Low Very Low
Neuropathic pain 40 5.00 Very Low Very Low Very Low
dorsal root ganglion 20 5.00 Very Low Very Low Very Low
Pain 20 5.00 Very Low Very Low Very Low
metalloproteinase 20 5.00 Very Low Very Low Very Low
Potency 15 5.00 Very Low Very Low Very Low
Multiple sclerosis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 120 84.80 Quite High
Alopecia 15 75.28 Quite High
Targeted Disruption 75 63.24 Quite High
Metastasis 50 10.40 Low Low
Ovarian Cancer 80 5.00 Very Low Very Low Very Low
Apoptosis 75 5.00 Very Low Very Low Very Low
Neuropathic Pain 50 5.00 Very Low Very Low Very Low
Infection 35 5.00 Very Low Very Low Very Low
Disease 35 5.00 Very Low Very Low Very Low
Fibrosis 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(Kitamura et al., 2009) expressed P2Y10 in NIH3T3 and HEK293 cells and found that transfectants show morphological changes and TNF?
Gene_expression (expressed) of P2Y10
1) Confidence 0.34 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0
P2Y10 have been expressed functionally in Flp-In™ CHO cells either alone or as a G16 fusion construct.
Gene_expression (expressed) of P2Y10
2) Confidence 0.34 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.18 Pain Relevance 0
To make things even more interesting, heterologously expressed P2Y10 is also activated by lysophosphatidyl serine, although it is much less potent than LPA on this target.


Gene_expression (expressed) of P2Y10
3) Confidence 0.34 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.08 Pain Relevance 0.04
P2Y10 is transcriptionally regulated by PU.1 and Spi-B of the Ets transcription factor family in B cells (Rao et al., 1999) and also expressed in platelets (Amisten et al., 2008).
Gene_expression (expressed) of P2Y10 in platelets
4) Confidence 0.34 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.26 Pain Relevance 0
In chronological order based on the first publication, these include the GPR87 (Tabata et al., 2007; Wetter et al., 2009), P2Y5 (Pasternack et al., 2008; Shimomura et al., 2008), P2Y10 (Murakami et al., 2008) and GPR35 (Oka et al., 2010) gene products.
Gene_expression (products) of P2Y10
5) Confidence 0.25 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0

General Comments

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