INT345149

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1) extracellular space (Enpp2) extracellular region (Enpp2)
plasma membrane (Lpar1) cytoplasm (Lpar1) signal transducer activity (Lpar1)
Enpp2 (Mus musculus)
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 15 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 24 96.20 Very High Very High Very High
Skin Cancer 3 93.92 High High
Embryonic Lethality 4 93.04 High High
Targeted Disruption 15 66.48 Quite High
Exencephaly /

Neural Tube Defects

1 62.72 Quite High
Hypoxia 1 47.92 Quite Low
Thrombosis 4 23.76 Low Low
Ovarian Cancer 16 12.56 Low Low
Apoptosis 15 5.00 Very Low Very Low Very Low
Metastasis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ten years after its original discovery, ATX was identified as a lysophospholipase D responsible for the production of LPA in serum (Umezu-Goto et al., 2002; Tokumura et al., 2002a).
lysophospholipase D Regulation (responsible) of Gene_expression (production) of LPA
1) Confidence 0.01 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.35 Pain Relevance 0

General Comments

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