INT345157

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Gtf3a) DNA binding (Gtf3a) cytoplasm (Lpar1)
signal transducer activity (Lpar1) signal transduction (Lpar1) RNA binding (Gtf3a)
Anatomy Link Frequency
connective tissue 2
Lpar1 (Mus musculus)
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 9 99.04 Very High Very High Very High
antagonist 15 43.36 Quite Low
agonist 15 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 6 99.04 Very High Very High Very High
Thrombosis 4 92.52 High High
Pathologic Neovascularization 1 91.92 High High
Wound Healing 2 81.76 Quite High
Rupture 1 81.72 Quite High
Atherosclerotic Plaque 1 78.44 Quite High
Myocardial Infarction 2 74.96 Quite High
Pulmonary Fibrosis 3 63.04 Quite High
Lung Injury 1 32.32 Quite Low
Cancer 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to being a mitogen, LPA increases connective tissue growth factor production, which promotes tissue fibrosis (Hahn et al., 2000; Muehlich et al., 2004; Vial et al., 2008).
LPA Positive_regulation (increases) of Gene_expression (production) of factor in connective tissue associated with fibrosis
1) Confidence 0.00 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.89 Pain Relevance 0.15

General Comments

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