INT345158

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sele) signal transduction (Lpar1) cell adhesion (Sele)
plasma membrane (Lpar1) cytoplasm (Lpar1) signal transducer activity (Lpar1)
Anatomy Link Frequency
endothelial cells 2
Lpar1 (Mus musculus)
Sele (Mus musculus)
Pain Link Frequency Relevance Heat
cva 1 26.64 Quite Low
antagonist 15 14.28 Low Low
agonist 15 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 2 71.52 Quite High
Hypotension 1 67.72 Quite High
Hypertension 1 65.80 Quite High
Reprotox - General 1 1 44.00 Quite Low
Embryonic Lethality 4 41.04 Quite Low
Targeted Disruption 15 38.88 Quite Low
Male Infertility 2 33.84 Quite Low
Apoptosis 15 30.24 Quite Low
Cv General 3 Under Development 1 26.64 Quite Low
Thrombosis 4 14.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The barrier function of vascular endothelial cells is altered by LPA (Schulze et al., 1997; Alexander et al., 1998; English et al., 1999), and LPA induces the expression of VCAM-1 and E-selectin on the surface of cultured human endothelial cells (Rizza et al., 1999).
LPA Positive_regulation (induces) of Gene_expression (expression) of E-selectin in endothelial cells
1) Confidence 0.02 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.21 Pain Relevance 0

General Comments

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