INT345171

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Trip6, Magi3) cell adhesion (Trip6) plasma membrane (Magi3)
cytoskeleton (Trip6) kinase activity (Magi3) cytoplasm (Trip6)
Anatomy Link Frequency
thyroid 2
Trip6 (Mus musculus)
Magi3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 70.00 Quite High
antagonist 30 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
Neuropathic pain 16 5.00 Very Low Very Low Very Low
dorsal root ganglion 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 30 100.00 Very High Very High Very High
Ovarian Cancer 32 87.24 High High
Aggression 4 63.08 Quite High
Pressure And Volume Under Development 4 44.92 Quite Low
Cancer 48 42.72 Quite Low
Metastasis 20 19.88 Low Low
Malignant Neoplastic Disease 4 18.52 Low Low
Targeted Disruption 30 11.72 Low Low
Neuropathic Pain 20 5.00 Very Low Very Low Very Low
Infection 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LPA2 receptor plays a unique role in chemoresistance, mediated through its C-terminal interaction with the thyroid receptor-interacting protein 6 (TRIP6), the pro-apoptotic transcription factor Siva-1 and the PSD-95/Disc-large/ZO-1 domain (PDZ domain)-binding proteins NHERF2 and MAGI-3 (Yamada et al., 2005; Lin et al., 2007; Zhang et al., 2007a,b; E et al., 2009).
TRIP6 Binding (interaction) of MAGI-3 in thyroid associated with apoptosis
1) Confidence 0.03 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.83 Pain Relevance 0.07
The LPA2 receptor plays a unique role in chemoresistance, mediated through its C-terminal interaction with the thyroid receptor-interacting protein 6 (TRIP6), the pro-apoptotic transcription factor Siva-1 and the PSD-95/Disc-large/ZO-1 domain (PDZ domain)-binding proteins NHERF2 and MAGI-3 (Yamada et al., 2005; Lin et al., 2007; Zhang et al., 2007a,b; E et al., 2009).
receptor-interacting protein 6 Binding (interaction) of MAGI-3 in thyroid associated with apoptosis
2) Confidence 0.03 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.83 Pain Relevance 0.07

General Comments

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