INT345172

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.19
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1, S1pr1) plasma membrane (Lpar1, S1pr1) signal transducer activity (Lpar1, S1pr1)
cytoplasm (Lpar1)
Lpar1 (Mus musculus)
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 99.24 Very High Very High Very High
alcohol 4 54.12 Quite High
antagonist 30 47.84 Quite Low
fibrosis 18 5.00 Very Low Very Low Very Low
Neuropathic pain 16 5.00 Very Low Very Low Very Low
dorsal root ganglion 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 48 98.44 Very High Very High Very High
Metastasis 20 32.76 Quite Low
Ovarian Cancer 32 5.00 Very Low Very Low Very Low
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Apoptosis 30 5.00 Very Low Very Low Very Low
Neuropathic Pain 20 5.00 Very Low Very Low Very Low
Infection 14 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Fibrosis 12 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because LPA concentrations can reach several micromoles in serum and tumour cell effusates (Baker et al., 2001; 2002; Sutphen et al., 2004), promiscuous activation of S1P1 by LPA in pathophysiological conditions may occur.
LPA Positive_regulation (activation) of S1P1 associated with cancer
1) Confidence 0.21 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.10 Pain Relevance 0.08
Conversely, LPA binds to (Kd= 2.3 ┬ÁM) and activates the S1P1 receptor as a low-affinity agonist (Lee et al., 1998).
LPA Positive_regulation (activates) of S1P1 receptor associated with agonist
2) Confidence 0.14 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.09 Pain Relevance 0.11

General Comments

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