INT345173

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.75
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Siva1) signal transduction (Lpar2) mitochondrion (Siva1)
nucleus (Siva1) signal transducer activity (Lpar2) cytoplasm (Siva1)
Siva1 (Mus musculus)
Lpar2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 58.76 Quite High
antagonist 15 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 15 93.72 High High
Ovarian Cancer 16 76.00 Quite High
Aggression 2 51.84 Quite High
Pressure And Volume Under Development 2 33.68 Quite Low
Cancer 24 31.48 Quite Low
Metastasis 10 8.64 Low Low
Malignant Neoplastic Disease 2 7.28 Low Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Neuropathic Pain 10 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPA2 binds Siva-1 through a–C 311XXC motif and the complex becomes polyubiquitinated and degraded by the proteasome, which leads to the attenuation of the DNA-damage-induced apoptosis.
Siva-1 Binding (binds) of LPA2 associated with apoptosis
1) Confidence 0.05 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.75 Pain Relevance 0.06

General Comments

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