INT345179

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1, Gpbar1) plasma membrane (Lpar1, Gpbar1) signal transducer activity (Lpar1, Gpbar1)
cytoplasm (Lpar1)
Lpar1 (Mus musculus)
Gpbar1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 75.44 Quite High
alcohol 4 26.24 Quite Low
antagonist 30 19.96 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
Neuropathic pain 16 5.00 Very Low Very Low Very Low
dorsal root ganglion 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 48 79.28 Quite High
Ovarian Cancer 32 5.00 Very Low Very Low Very Low
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Apoptosis 30 5.00 Very Low Very Low Very Low
Metastasis 20 5.00 Very Low Very Low Very Low
Neuropathic Pain 20 5.00 Very Low Very Low Very Low
Infection 14 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Fibrosis 12 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronologically, the endothelial gene (EDG) family was the first shown to encode GPCR specific for S1P and LPA.
LPA Binding (specific) of GPCR
1) Confidence 0.05 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.07 Pain Relevance 0.03
The LPA GPCR are the most studied and best understood targets of LPA.
LPA Binding (targets) of GPCR
2) Confidence 0.04 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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