INT345182

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Lpar1, Gsn) protein complex (Gsn) signal transducer activity (Lpar1)
cytosol (Gsn) signal transduction (Lpar1) extracellular space (Gsn)
Anatomy Link Frequency
epithelial cells 1
Lpar1 (Mus musculus)
Gsn (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 4 85.80 High High
antagonist 30 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
Neuropathic pain 16 5.00 Very Low Very Low Very Low
dorsal root ganglion 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bordatella Infection 4 26.20 Quite Low
Hyperplasia 4 18.68 Low Low
Skin Cancer 6 8.80 Low Low
Cancer 48 5.00 Very Low Very Low Very Low
Ovarian Cancer 32 5.00 Very Low Very Low Very Low
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Apoptosis 30 5.00 Very Low Very Low Very Low
Metastasis 20 5.00 Very Low Very Low Very Low
Neuropathic Pain 20 5.00 Very Low Very Low Very Low
Infection 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, there is compelling evidence for the interaction of LPA with actin-binding proteins, including gelsolin, formin, adseverin (Meerschaert et al., 1998; Goetzl et al., 2000b; Mintzer et al., 2006) and villin, the later of which is restricted to epithelial cells (Khurana et al., 2008; Tomar et al., 2009).
LPA Binding (interaction) of gelsolin in epithelial cells
1) Confidence 0.04 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0.04
This polarized production coupled with the direct interaction of LPA with members of the gelsolin-villin family proteins implicates it in the cellular compass mechanism underlying directional cell migration.
LPA Binding (interaction) of gelsolin
2) Confidence 0.04 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0

General Comments

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