INT345190

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.19
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) signal transduction (Lpar1) extracellular region (Il6)
plasma membrane (Lpar1) cytoplasm (Lpar1) signal transducer activity (Lpar1)
Lpar1 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 15 88.80 High High
Neuropathic pain 8 31.04 Quite Low
Demyelination 2 21.44 Low Low
dorsal root ganglion 4 18.60 Low Low
agonist 15 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 1 98.88 Very High Very High Very High
Breast Cancer 3 98.64 Very High Very High Very High
Metastasis 10 97.92 Very High Very High Very High
Osteoporosis 3 94.08 High High
Cancer 24 89.68 High High
Bordatella Infection 2 89.68 High High
Apoptosis 15 74.88 Quite High
Congenital Anomalies 2 60.92 Quite High
Targeted Disruption 15 54.72 Quite High
Disease 7 52.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPA1 regulates the secretion of IL-6 and IL-8, which are potent bone resorption stimulators.
LPA1 Regulation (regulates) of Localization (secretion) of IL-6 associated with hypercalcemia
1) Confidence 0.05 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 1.19 Pain Relevance 0.04

General Comments

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