INT345211

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Grm7) plasma membrane (Grm7) neurological system process (Grm7)
protein complex (Grm7) signal transducer activity (Grm7)
Anatomy Link Frequency
ventral 1
Grm7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 28 98.88 Very High Very High Very High
Spinal cord 1 98.72 Very High Very High Very High
Ventral tegmentum 1 96.80 Very High Very High Very High
IPN 1 92.84 High High
Hyperalgesia 1 92.00 High High
agonist 37 90.76 High High
intrathecal 1 87.48 High High
antidepressant 2 83.08 Quite High
Pain 2 71.92 Quite High
depression 5 71.56 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 1 92.84 High High
Hyperalgesia 1 92.00 High High
Pain 2 71.92 Quite High
Depression 5 71.56 Quite High
Disease 65 69.04 Quite High
Psychosis 3 55.12 Quite High
Anxiety Disorder 1 31.24 Quite Low
Schizophrenia 1 29.96 Quite Low
Cognitive Disorder 1 10.68 Low Low
Parkinson's Disease 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, activation of group III receptors, especially mGlu7, has been shown to inhibit glutamate release onto dopaminergic neurones in the ventral tegmental area, and systemic injection of ACPT-I has been shown to produce antipsychotic effects in rodents (Palucha-Poniewiera et al., 2008).
Positive_regulation (activation) of mGlu7 in ventral associated with ventral tegmentum and glutamate
1) Confidence 0.02 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989582 Disease Relevance 0.64 Pain Relevance 0.66

General Comments

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