INT345253

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Context Info
Confidence 0.16
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.07
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fads1) oxidoreductase activity (Fads1) aging (Fads1)
endoplasmic reticulum (Fads1) nucleus (Fads1) response to stress (Fads1)
Anatomy Link Frequency
brains 2
Fads1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 72 97.68 Very High Very High Very High
Serotonin 15 5.00 Very Low Very Low Very Low
antidepressant 13 5.00 Very Low Very Low Very Low
Dopamine 8 5.00 Very Low Very Low Very Low
Nucleus accumbens 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
fluoxetine 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Suicidal Behaviour 10 98.80 Very High Very High Very High
Depression 57 97.68 Very High Very High Very High
Obesity 1 85.20 High High
Post-partum Depression 30 62.68 Quite High
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Stress 7 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of FADS1 and several other genes involved in lipid metabolism was also decreased in individuals who completed suicide [86]; however, no alterations in any of the n-3 PUFAs were found in postmortem brains from suicide completers, even in those individuals with a diagnosis of major depression [87, 88].


Negative_regulation (decreased) of Gene_expression (Expression) of FADS1 in brains associated with suicidal behaviour and depression
1) Confidence 0.16 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 1.07 Pain Relevance 0.30

General Comments

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