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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) plasma membrane (Slc3a1) carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
brain 2
brainstem 2
Slc3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 5 98.16 Very High Very High Very High
Nucleus accumbens 5 97.96 Very High Very High Very High
dopamine receptor 3 96.24 Very High Very High Very High
medulla 4 95.40 Very High Very High Very High
depression 73 91.72 High High
Dopamine 41 90.88 High High
gABA 3 70.36 Quite High
agonist 7 69.36 Quite High
Serotonin 16 61.68 Quite High
monoamine 2 60.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 99.74 Very High Very High Very High
Depression 58 91.72 High High
Neurodegenerative Disease 4 83.04 Quite High
Disease 29 81.88 Quite High
Suicidal Behaviour 10 77.16 Quite High
Attention Deficit Hyperactivity Disorder 4 67.44 Quite High
Stress 7 58.48 Quite High
Post-partum Depression 30 50.00 Quite Low
Urological Neuroanatomy 3 27.20 Quite Low
Sleep Disorders 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since our model predicts that the loss of D2 receptors in the BG may result in an increase in wakefulness, the reduced wakefulness in D2 knockout mice may be due to the absence of functional D2 receptors in the extra-BG sites, such as the cerebral cortex, BF, LH, and other wake-promoting cell groups in the brainstem and caudal hypothalamus (Figure 2B).
Positive_regulation (due) of Negative_regulation (absence) of D2 in brainstem associated with targeted disruption, medulla and cerebral cortex
1) Confidence 0.07 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2996256 Disease Relevance 0.34 Pain Relevance 0.26
A trend towards a decrease in D2-like receptor binding was also observed in virgin females with decreased brain DHA, suggesting that the decrease in D2-like receptor binding in this brain region resulted from the change in brain DHA status, but may be augmented in the postpartum female.
Positive_regulation (augmented) of Negative_regulation (decrease) of D2 in brain
2) Confidence 0.05 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.97 Pain Relevance 0.64

General Comments

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