INT345270

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tirap) intracellular (Tirap) cytoplasm (Tirap)
Anatomy Link Frequency
macrophages 1
Tirap (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 3 38.88 Quite Low
Arthritis 1 14.08 Low Low
cytokine 3 11.32 Low Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenovirus Infection 1 85.80 High High
Apoptosis 6 67.64 Quite High
Infection 8 41.60 Quite Low
INFLAMMATION 4 38.52 Quite Low
Autoimmune Disease 25 20.08 Low Low
Systemic Lupus Erythematosus 85 17.84 Low Low
Arthritis 1 14.08 Low Low
Disease 27 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As evidence that the inflammasome response operates independently of other known DNA-sensing mechanisms, it was shown that, following exposure to adenovirus DNA, caspase-1 processing was intact in macrophages that lack both TLR9 and the TLR adaptor protein MyD88.
Negative_regulation (lack) of TLR adaptor protein MyD88 in macrophages
1) Confidence 0.02 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.15 Pain Relevance 0

General Comments

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