INT345281

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CASP1, Nlrp3) cytosol (CASP1) peptidase activity (CASP1)
signal transduction (CASP1) intracellular (CASP1)
CASP1 (Homo sapiens)
Nlrp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 3 60.92 Quite High
cytokine 3 33.36 Quite Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenovirus Infection 1 91.44 High High
Apoptosis 6 89.68 High High
Infection 8 63.64 Quite High
INFLAMMATION 4 60.56 Quite High
Systemic Lupus Erythematosus 85 5.00 Very Low Very Low Very Low
Disease 27 5.00 Very Low Very Low Very Low
Autoimmune Disease 25 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Immunization 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NALP3 and ASC are thought to function in the recruitment of caspase-1 to the inflammasome complex, which thereby leads to the maturation of pro-IL-1?.
caspase-1 Binding (recruitment) of NALP3
1) Confidence 0.02 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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