INT345304

Context Info Confidence 0.08 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.20 Pain Relevance 0.45

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2) proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)

MMP14 (Homo sapiens) MMP2 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 46 99.48 cytokine 2 79.48 chemokine 3 79.04 Inflammation 15 5.00 rheumatoid arthritis 7 5.00 Multiple sclerosis 4 5.00 Pain 3 5.00 Potency 2 5.00 Neuropathic pain 1 5.00 Demyelination 1 5.00

Disease Link Frequency Relevance Heat Cancer 38 74.16 Malignant Neoplastic Disease 2 18.80 INFLAMMATION 15 5.00 Metastasis 9 5.00 Disease 9 5.00 Rheumatoid Arthritis 7 5.00 Breast Cancer 6 5.00 Demyelinating Disease 5 5.00 Skin Cancer 5 5.00 Carcinoma 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, membrane-bound MMPs are known to cleave and activate secreted MMPs, first described for the activation of MMP-2 by MMP-14 through interaction with TIMP-2 [30, 71].

MMP-14 Positive_regulation (activation) of MMP-2 associated with metalloproteinase

1) Confidence 0.08 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.20 Pain Relevance 0.45

General Comments

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