INT345314

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Context Info
Confidence 0.30
First Reported 2011
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 6.07
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP17) extracellular region (MMP17) proteinaceous extracellular matrix (MMP17)
plasma membrane (MMP17)
Anatomy Link Frequency
lymph nodes 1
B cells 1
MDA-MB-231 1
MMP17 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 184 97.88 Very High Very High Very High
Multiple sclerosis 16 89.76 High High
Neuropathic pain 4 78.92 Quite High
Inflammation 60 67.12 Quite High
chemokine 12 61.84 Quite High
Demyelination 4 55.60 Quite High
rheumatoid arthritis 28 52.40 Quite High
Pain 12 29.20 Quite Low
cytokine 8 9.28 Low Low
Potency 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 4 99.64 Very High Very High Very High
Breast Cancer 24 99.60 Very High Very High Very High
Cancer 152 99.40 Very High Very High Very High
Metastasis 36 99.04 Very High Very High Very High
Demyelinating Disease 20 89.76 High High
Ovarian Cancer 4 88.24 High High
Glioblastoma 4 84.60 Quite High
Anaplastic Astrocytoma 4 83.88 Quite High
Brain Tumor 8 82.92 Quite High
Prostate Cancer 4 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is an excellent review on the properties and expression of MMP-17 and MMP-25 in cancer published by Sohail and coworkers [57].
Gene_expression (expression) of MMP-17 associated with cancer
1) Confidence 0.30 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.68 Pain Relevance 0.22
MMP-17 is significantly expressed in B cells.
Gene_expression (expressed) of MMP-17 in B cells
2) Confidence 0.26 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.88 Pain Relevance 0.41
MMP-17 is strongly expressed in human breast cancer cells and in metastatic cells in human lymph nodes [117].
Gene_expression (expressed) of MMP-17 in lymph nodes associated with breast cancer
3) Confidence 0.26 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.76 Pain Relevance 0.17
Chabottaux et al. applied experimental and spontaneous models of lung metastasis using human breast adenocarcinoma MDA-MB-231 cells overexpressing or not MMP-17 and found that MMP-17 promotes lung metastasis by disturbing the tumor vessel integrity and thereby facilitating tumor cell intravasation [118].
Neg (not) Gene_expression (overexpressing) of MMP-17 in MDA-MB-231 associated with adenocarcinoma, cancer and metastasis
4) Confidence 0.23 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.76 Pain Relevance 0.18

General Comments

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