INT345320

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Context Info
Confidence 0.16
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.39
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP23B) reproduction (MMP23B) endoplasmic reticulum (MMP23B)
proteinaceous extracellular matrix (MMP23B) intracellular (MMP23B)
Anatomy Link Frequency
cartilage 1
MMP23B (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 99.84 Very High Very High Very High
metalloproteinase 92 98.64 Very High Very High Very High
Inflammation 30 97.32 Very High Very High Very High
Multiple sclerosis 8 96.56 Very High Very High Very High
Demyelination 2 94.00 High High
Neuropathic pain 2 48.88 Quite Low
rheumatoid arthritis 14 22.36 Low Low
chemokine 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tendinopathy 2 99.52 Very High Very High Very High
INFLAMMATION 30 97.32 Very High Very High Very High
Demyelinating Disease 10 96.56 Very High Very High Very High
Neuropathic Pain 2 48.88 Quite Low
Renal Disease 2 46.64 Quite Low
Frailty 2 45.52 Quite Low
Atherosclerotic Plaque 2 40.16 Quite Low
Atherosclerosis 4 35.88 Quite Low
Rheumatoid Arthritis 14 22.36 Low Low
Cancer 76 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ADAM-12 and MMP-23 are coexpressed in painful tendinopathy [139] suggesting a role for these in this inflammatory disorder.



Gene_expression (coexpressed) of MMP-23 associated with pain, inflammation and tendinopathy
1) Confidence 0.16 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.69 Pain Relevance 0.48
MMP-23 mRNA is expressed in chondrocytes and osteoblasts, suggesting a role in some aspect of cartilage or bone formation [138].
Gene_expression (expressed) of MMP-23 mRNA in cartilage
2) Confidence 0.16 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.70 Pain Relevance 0.51

General Comments

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