INT34534

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Context Info
Confidence 0.37
First Reported 1982
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 2
Penk (Rattus norvegicus)
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 37 100.00 Very High Very High Very High
opiate 13 100.00 Very High Very High Very High
Central nervous system 1 89.60 High High
Endogenous opioid 1 89.40 High High
Morphine 1 70.68 Quite High
Hippocampus 1 61.52 Quite High
cerebral cortex 1 60.84 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This data suggest that administration of lithium to rats in small doses reduces opiate receptor binding of enkephalin.
enkephalin Binding (binding) of opiate receptor associated with enkephalin and opiate
1) Confidence 0.37 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6289161 Disease Relevance 0 Pain Relevance 0.94
When 72% of the phosphatidylinositol in the rat brain membranes was hydrolyzed by phosphatidylinositol-specific phospholipase C, the affinity of opiate receptor for [D-Ala2,-D-Leu5] enkephalin was almost doubled and maximal binding of [D-Ala2,-D-Leu5] enkephalin was decreased to 87% of control.
enkephalin Binding (affinity) of opiate receptor in brain associated with enkephalin and opiate
2) Confidence 0.09 Published 1987 Journal Toxicon Section Abstract Doc Link 3039692 Disease Relevance 0 Pain Relevance 0.68
However, the affinity of opiate receptor for [D-Ala2,-D-Leu5] enkephalin was not influenced, and maximal binding was decreased to 32% of the control when 61% of phosphatidylcholine was hydrolyzed.
enkephalin Binding (affinity) of opiate receptor associated with enkephalin and opiate
3) Confidence 0.07 Published 1987 Journal Toxicon Section Abstract Doc Link 3039692 Disease Relevance 0 Pain Relevance 1.02
The obtained data show that enkephalin effects in this experimental test to a certain extent correlate with peptides' ability of binding tightly with delta-opiate brain receptors.
enkephalin Binding (binding) of delta-opiate in brain associated with opiate and enkephalin
4) Confidence 0.02 Published 1983 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 6359758 Disease Relevance 0 Pain Relevance 1.00

General Comments

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