INT345348

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc18a2) aging (Slc18a2) enzyme binding (Slc18a2)
transmembrane transport (Slc18a2) cytoplasm (Slc18a2)
Anatomy Link Frequency
striatum 2
Slc18a2 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 1 94.76 High High
monoamine 1 94.32 High High
Dopamine 13 92.48 High High
Substantia nigra 12 48.08 Quite Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Neurobehavioral 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 110 82.60 Quite High
Parkinson's Disease 50 59.00 Quite High
Syndrome 1 50.00 Quite Low
Neurologic Gait Disorders 2 41.88 Quite Low
Death 8 40.80 Quite Low
Hypokinesia 3 40.44 Quite Low
Tremor 3 33.80 Quite Low
Apoptosis 5 8.08 Low Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of C57BL mice to an organochlorine pesticide (increased the expression of both DAT and VMAT2 in the striatum).Sanchez-Ramos et al. [62] showed that dieldrin is selectively toxic to dopaminergic neurons compared to striatal GABAergic neurons in primary mesencephalic cultures.

2.4.1.4c.ii.

Positive_regulation (increased) of Gene_expression (expression) of VMAT2 in striatum associated with gabaergic
1) Confidence 0.28 Published 2010 Journal Neurology Research International Section Body Doc Link PMC2989867 Disease Relevance 0.41 Pain Relevance 0.27

General Comments

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