INT345350

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.79
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Casp3, Prkcd) cytoplasm (Casp3, Prkcd) cytosol (Casp3, Prkcd)
nucleus (Casp3, Prkcd) endoplasmic reticulum (Prkcd) intracellular (Casp3)
Anatomy Link Frequency
cleavage 1
Casp3 (Mus musculus)
Prkcd (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 1 50.16 Quite High
monoamine 1 37.04 Quite Low
Dopamine 13 35.20 Quite Low
sodium channel 1 12.32 Low Low
Substantia nigra 12 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Neurobehavioral 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 5 99.84 Very High Very High Very High
Death 8 99.24 Very High Very High Very High
Disease 110 74.60 Quite High
Syndrome 1 50.00 Quite Low
Toxicity 5 18.00 Low Low
Parkinson's Disease 50 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Hypokinesia 3 5.00 Very Low Very Low Very Low
Tremor 3 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently caspase 3 has been identified as a critical factor in apoptotic cell death in dopaminergic neurons [65].PKCd is an important apoptotic substrate for caspase-3, and subsequent studies have implicated caspase-3-mediated proteolytic activation of PKCd in apoptotic cell death [66–69].Dieldrin treatment induced dose and time-dependent proteolytic cleavage of native PKCd (72 and 74?
caspase-3-mediated Positive_regulation (activation) of PKCd in cleavage associated with apoptosis and death
1) Confidence 0.05 Published 2010 Journal Neurology Research International Section Body Doc Link PMC2989867 Disease Relevance 0.79 Pain Relevance 0.03

General Comments

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