INT345367

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.90
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Insrr)
Anatomy Link Frequency
endothelial cell 2
dorsal horn 2
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 21 99.16 Very High Very High Very High
Pain 19 98.58 Very High Very High Very High
Thermal hyperalgesia 8 97.28 Very High Very High Very High
Hyperalgesia 2 95.80 Very High Very High Very High
allodynia 9 94.40 High High
Eae 16 91.56 High High
Neuropathic pain 20 89.52 High High
Acute pain 2 89.00 High High
nMDA receptor 8 80.20 Quite High
antagonist 2 77.96 Quite High
Disease Link Frequency Relevance Heat
Pain 22 98.58 Very High Very High Very High
Hyperalgesia 10 97.28 Very High Very High Very High
Neuropathic Pain 32 94.40 High High
Cancer 115 92.24 High High
Inflammatory Pain 9 91.56 High High
Targeted Disruption 70 84.00 Quite High
Metastasis 62 75.76 Quite High
INFLAMMATION 10 75.00 Quite High
Stomach Cancer 1 71.52 Quite High
Prostate Cancer 1 70.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Formalin-induced pain behavior was attenuated in the second phase, and this correlated with diminished tyrosine phosphorylation of N-methyl-D-aspartic acid (NMDA) receptor subunit NR2B in the dorsal horn.
Negative_regulation (diminished) of Phosphorylation (phosphorylation) of receptor in dorsal horn associated with pain and dorsal horn
1) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2992507 Disease Relevance 1.75 Pain Relevance 1.50
These mechanisms include: blocking the binding of VEGF121 and VEGF165 to the KDR/Flk-1 receptor, which mediates endothelial cell motility and proliferation; blocking phosphorylation of the tyrosine receptor; and blocking activation of the intracellular signaling kinases ERK, p38 MAPK, and p125 FAK [34,35].
Negative_regulation (blocking) of Phosphorylation (phosphorylation) of receptor in endothelial cell
2) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.14 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox